3gi3 Summary


Crystal structure of a N-Phenyl-N'-Naphthylurea analog in complex with p38 MAP kinase

The structure was published by Cirillo, P.F., Hickey, E.R., Moss, N., et al., Takahashi, H., Tsang, M., and Xiong, Z., in 2009 in a paper entitled "Discovery and characterization of the N-phenyl-N'-naphthylurea class of p38 kinase inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 328 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 91%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q16539) protein phosphorylationsearch cartilage condensationsearch response to muramyl dipeptidesearch TRIF-dependent toll-like receptor signaling pathwaysearch apoptotic processsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch positive regulation of myoblast fusionsearch cell surface receptor signaling pathwaysearch toll-like receptor 10 signaling pathwaysearch toll-like receptor TLR1:TLR2 signaling pathwaysearch transcription, DNA-templatedsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch chemotaxissearch striated muscle cell differentiationsearch DNA damage checkpointsearch toll-like receptor signaling pathwaysearch positive regulation of protein import into nucleussearch Ras protein signal transductionsearch muscle cell differentiationsearch osteoclast differentiationsearch toll-like receptor 3 signaling pathwaysearch platelet activationsearch activation of MAPK activitysearch MyD88-independent toll-like receptor signaling pathwaysearch gene expressionsearch positive regulation of erythrocyte differentiationsearch toll-like receptor 5 signaling pathwaysearch positive regulation of reactive oxygen species metabolic processsearch toll-like receptor 4 signaling pathwaysearch cell morphogenesissearch positive regulation of transcription from RNA polymerase II promotersearch stress-induced premature senescencesearch signal transductionsearch blood coagulationsearch p38MAPK cascadesearch fatty acid oxidationsearch positive regulation of muscle cell differentiationsearch stress-activated MAPK cascadesearch cellular response to vascular endothelial growth factor stimulussearch positive regulation of myoblast differentiationsearch regulation of transcription from RNA polymerase II promotersearch 3'-UTR-mediated mRNA stabilizationsearch signal transduction in response to DNA damagesearch vascular endothelial growth factor receptor signaling pathwaysearch MyD88-dependent toll-like receptor signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch glucose metabolic processsearch neurotrophin TRK receptor signaling pathwaysearch response to stresssearch peptidyl-serine phosphorylationsearch myoblast differentiation involved in skeletal muscle regenerationsearch positive regulation of myotube differentiationsearch phosphorylationsearch RNA metabolic processsearch intracellular signal transductionsearch positive regulation of blood vessel endothelial cell migrationsearch regulation of transcription, DNA-templatedsearch angiogenesissearch toll-like receptor 9 signaling pathwaysearch skeletal muscle tissue developmentsearch mRNA metabolic processsearch cellular component movementsearch toll-like receptor 2 signaling pathwaysearch innate immune responsesearch response to lipopolysaccharidesearch negative regulation of canonical Wnt signaling pathwaysearch lipopolysaccharide-mediated signaling pathwaysearch cellular response to lipopolysaccharidesearch chondrocyte differentiationsearch cellular response to DNA damage stimulussearch cellular response to ionizing radiationsearch protein bindingsearch MAP kinase kinase activitysearch protein kinase activitysearch ATP bindingsearch MAP kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch kinase activitysearch NFAT protein bindingsearch nucleotide bindingsearch protein serine/threonine kinase activitysearch transferase activitysearch nucleussearch mitochondrionsearch cytoplasmsearch nucleoplasmsearch cytosolsearch cellsearch spindle polesearch extracellular vesicular exosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch