3gft Summary


PDB entry 3gft (supersedes 2pmx)

Human K-Ras in complex with a GTP analogue

A publication describing this structure is not available. The depositing authors are Tong, Y.search; Tempel, W.search; Shen, L.search; Arrowsmith, C.H.search; Edwards, A.M.search; Sundstrom, M.search; Weigelt, J.search; Bochkarev, A.search; Park, H.search; Structural Genomics Consortium (SGC)search

This crystal structure was determined using X-ray diffraction at a resolution of 2.27 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of GTPase KRas.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A GTPase KRas Not available
Homo sapienssearch < 90% 187 89%
B GTPase KRas P01116 (1-164) (RASK_HUMAN)search Homo sapienssearch < 90% 187 89%
C GTPase KRas P01116 (1-164) (RASK_HUMAN)search Homo sapienssearch < 90% 187 89%
D GTPase KRas P01116 (1-164) (RASK_HUMAN)search Homo sapienssearch < 90% 187 89%
E GTPase KRas P01116 (1-164) (RASK_HUMAN)search Homo sapienssearch < 90% 187 89%
F GTPase KRas P01116 (1-164) (RASK_HUMAN)search Homo sapienssearch < 90% 187 89%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01116 (1 - 164) GTPase KRas Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F P-loop containing nucleotide triphosphate hydrolasessearch Ras familysearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B, C, D, E, F (P01116) GTP catabolic processsearch signal transductionsearch small GTPase mediated signal transductionsearch GTP bindingsearch membranesearch

Chain InterPro annotation
A, B, C, D, E, F Small GTPase superfamilysearch Small GTP-binding protein domainsearch Small GTPase superfamily, Ras typesearch P-loop containing nucleoside triphosphate hydrolasesearch