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Structural basis for the chemical rescue of Src kinase activity

X-ray diffraction
2.2Å resolution
PDB entry 3geq coloured by chain, front view.
PDB entry 3geq coloured by chain, side view.
PDB entry 3geq coloured by chain, top view.
Source organism: Gallus gallus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Proto-oncogene tyrosine-protein kinase Src
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Multimeric state: monomeric
Accessible surface area: 14199.11 Å2
Buried surface area: 699.91 Å2
Dissociation area: 349.96 Å2
Dissociation energy (ΔGdiss): 4.67 kcal/mol
Dissociation entropy (TΔSdiss): 4.12 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132629
Assembly 2
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Assembly Name: Proto-oncogene tyrosine-protein kinase Src
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Multimeric state: monomeric
Accessible surface area: 14054.58 Å2
Buried surface area: 702.19 Å2
Dissociation area: 351.09 Å2
Dissociation energy (ΔGdiss): 4.52 kcal/mol
Dissociation entropy (TΔSdiss): 4.12 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132629

Macromolecules

Proto-oncogene tyrosine-protein kinase Src
Chains: A, B
Length: 286 amino acids
Theoretical weight: 32.64 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00523 (Residues: 251-533; Coverage: 53%)
Gene name: SRC
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Proto-oncogene tyrosine-protein kinase Src in PDB entry 3geq, assembly 1, front view.
Proto-oncogene tyrosine-protein kinase Src in PDB entry 3geq, assembly 1, side view.
Proto-oncogene tyrosine-protein kinase Src in PDB entry 3geq, assembly 1, top view.
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