3gd2

X-ray diffraction
3.2Å resolution

isoxazole ligand bound to farnesoid X receptor (FXR)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-163582 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bile acid receptor Chain: A
Molecule details ›
Chain: A
Length: 229 amino acids
Theoretical weight: 26.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96RI1 (Residues: 260-486; Coverage: 47%)
Gene names: BAR, FXR, HRR1, NR1H4, RIP14
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
activator peptide Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.31 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: F23
Unit cell:
a: 158.749Å b: 158.749Å c: 158.749Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.242 0.238 0.297
Expression systems:
  • Escherichia coli
  • Not provided