3gd2 Summary

pdbe.org/3gd2
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isoxazole ligand bound to farnesoid X receptor (FXR)

The structure was published by Bass, J.Y., Caldwell, R.D., Caravella, J.A., et al., Todd, D., Williams, S.P., and Wisely, G.B., in 2009 in a paper entitled "Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.2 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Bile acid receptor and activator peptide.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Bile acid receptor Q96RI1 (260-486) (NR1H4_HUMAN)search Homo sapienssearch < 90% 229 99%
B activator peptide Not available
Not available Not available 11 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q96RI1 (260 - 486) Bile acid receptor Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
B

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (Q96RI1) steroid hormone receptor activitysearch DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch thyroid hormone receptor activitysearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Thyroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
B