3gcv Summary


Human P38 MAP Kinase in Complex with RL62

The structure was published by Simard, J.R., Getlik, M., Grutter, C., et al., Wulfert, S., Rabiller, M., and Rauh, D., in 2009 in a paper entitled "Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 336 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q16539) response to lipopolysaccharidesearch p38MAPK cascadesearch toll-like receptor 3 signaling pathwaysearch peptidyl-serine phosphorylationsearch positive regulation of myotube differentiationsearch RNA metabolic processsearch striated muscle cell differentiationsearch chondrocyte differentiationsearch response to muramyl dipeptidesearch stress-activated MAPK cascadesearch intracellular signal transductionsearch glucose metabolic processsearch blood coagulationsearch cartilage condensationsearch protein phosphorylationsearch MyD88-dependent toll-like receptor signaling pathwaysearch positive regulation of blood vessel endothelial cell migrationsearch stress-induced premature senescencesearch cell surface receptor signaling pathwaysearch 3'-UTR-mediated mRNA stabilizationsearch regulation of transcription, DNA-templatedsearch TRIF-dependent toll-like receptor signaling pathwaysearch toll-like receptor signaling pathwaysearch positive regulation of myoblast fusionsearch mRNA metabolic processsearch positive regulation of reactive oxygen species metabolic processsearch angiogenesissearch cellular response to DNA damage stimulussearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch platelet activationsearch lipopolysaccharide-mediated signaling pathwaysearch osteoclast differentiationsearch negative regulation of canonical Wnt signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch toll-like receptor 2 signaling pathwaysearch transcription, DNA-templatedsearch cellular response to lipopolysaccharidesearch innate immune responsesearch vascular endothelial growth factor receptor signaling pathwaysearch gene expressionsearch positive regulation of transcription from RNA polymerase II promotersearch toll-like receptor TLR1:TLR2 signaling pathwaysearch fatty acid oxidationsearch positive regulation of myoblast differentiationsearch toll-like receptor 5 signaling pathwaysearch positive regulation of muscle cell differentiationsearch regulation of transcription from RNA polymerase II promotersearch muscle cell differentiationsearch neurotrophin TRK receptor signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch cell morphogenesissearch Ras protein signal transductionsearch cellular component movementsearch skeletal muscle tissue developmentsearch activation of MAPK activitysearch apoptotic processsearch signal transduction in response to DNA damagesearch toll-like receptor 10 signaling pathwaysearch phosphorylationsearch myoblast differentiation involved in skeletal muscle regenerationsearch toll-like receptor 4 signaling pathwaysearch cellular response to vascular endothelial growth factor stimulussearch toll-like receptor 9 signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch positive regulation of protein import into nucleussearch response to stresssearch signal transductionsearch DNA damage checkpointsearch chemotaxissearch positive regulation of erythrocyte differentiationsearch cellular response to ionizing radiationsearch protein bindingsearch nucleotide bindingsearch MAP kinase activitysearch NFAT protein bindingsearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch kinase activitysearch MAP kinase kinase activitysearch transferase activitysearch cytoplasmsearch nucleoplasmsearch cytosolsearch nucleussearch mitochondrionsearch extracellular vesicular exosomesearch cellsearch spindle polesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch