3gcu Summary


Human P38 MAP kinase in complex with RL48

The structure was published by Simard, J.R., Getlik, M., Grutter, C., et al., Wulfert, S., Rabiller, M., and Rauh, D., in 2009 in a paper entitled "Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Mitogen-activated protein kinase 14.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 94%
B Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (Q16539) positive regulation of blood vessel endothelial cell migrationsearch DNA damage checkpointsearch activation of MAPK activitysearch cell morphogenesissearch cartilage condensationsearch angiogenesissearch chondrocyte differentiationsearch toll-like receptor signaling pathwaysearch MyD88-dependent toll-like receptor signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch glucose metabolic processsearch transcription, DNA-templatedsearch regulation of transcription, DNA-templatedsearch regulation of transcription from RNA polymerase II promotersearch protein phosphorylationsearch apoptotic processsearch movement of cell or subcellular componentsearch chemotaxissearch cellular response to DNA damage stimulussearch organelle organizationsearch mitochondrion organizationsearch signal transductionsearch cell surface receptor signaling pathwaysearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch Ras protein signal transductionsearch skeletal muscle tissue developmentsearch blood coagulationsearch gene expressionsearch positive regulation of myotube differentiationsearch myoblast differentiation involved in skeletal muscle regenerationsearch phosphorylationsearch peptidyl-serine phosphorylationsearch fatty acid oxidationsearch platelet activationsearch osteoclast differentiationsearch lipopolysaccharide-mediated signaling pathwaysearch response to muramyl dipeptidesearch response to lipopolysaccharidesearch toll-like receptor 2 signaling pathwaysearch toll-like receptor 3 signaling pathwaysearch toll-like receptor 4 signaling pathwaysearch toll-like receptor 5 signaling pathwaysearch toll-like receptor 9 signaling pathwaysearch toll-like receptor 10 signaling pathwaysearch intracellular signal transductionsearch TRIF-dependent toll-like receptor signaling pathwaysearch cellular response to vascular endothelial growth factor stimulussearch p38MAPK cascadesearch toll-like receptor TLR1:TLR2 signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch positive regulation of protein import into nucleussearch muscle cell differentiationsearch signal transduction in response to DNA damagesearch innate immune responsesearch positive regulation of erythrocyte differentiationsearch positive regulation of myoblast differentiationsearch positive regulation of transcription from RNA polymerase II promotersearch vascular endothelial growth factor receptor signaling pathwaysearch neurotrophin TRK receptor signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch striated muscle cell differentiationsearch positive regulation of muscle cell differentiationsearch stress-activated MAPK cascadesearch 3'-UTR-mediated mRNA stabilizationsearch cellular response to lipopolysaccharidesearch cellular response to ionizing radiationsearch negative regulation of canonical Wnt signaling pathwaysearch positive regulation of brown fat cell differentiationsearch stress-induced premature senescencesearch positive regulation of myoblast fusionsearch positive regulation of reactive oxygen species metabolic processsearch nucleotide bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch MAP kinase activitysearch MAP kinase kinase activitysearch protein bindingsearch ATP bindingsearch kinase activitysearch transferase activitysearch transferase activity, transferring phosphorus-containing groupssearch NFAT protein bindingsearch spindle polesearch cellsearch nucleussearch nucleoplasmsearch cytoplasmsearch mitochondrionsearch cytosolsearch extracellular vesicular exosomesearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch