3gcu Summary


Human P38 MAP kinase in complex with RL48

The structure was published by Simard, J.R., Getlik, M., Grutter, C., et al., Wulfert, S., Rabiller, M., and Rauh, D., in 2009 in a paper entitled "Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Mitogen-activated protein kinase 14.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 94%
B Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (Q16539) ATP bindingsearch protein kinase activitysearch NFAT protein bindingsearch protein bindingsearch MAP kinase kinase activitysearch transferase activitysearch kinase activitysearch MAP kinase activitysearch nucleotide bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch muscle cell differentiationsearch cartilage condensationsearch phosphorylationsearch MyD88-dependent toll-like receptor signaling pathwaysearch signal transduction in response to DNA damagesearch toll-like receptor 3 signaling pathwaysearch positive regulation of brown fat cell differentiationsearch angiogenesissearch peptidyl-serine phosphorylationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch cell morphogenesissearch vascular endothelial growth factor receptor signaling pathwaysearch response to lipopolysaccharidesearch mitochondrion organizationsearch toll-like receptor 2 signaling pathwaysearch positive regulation of erythrocyte differentiationsearch positive regulation of myoblast differentiationsearch fatty acid oxidationsearch p38MAPK cascadesearch blood coagulationsearch toll-like receptor 9 signaling pathwaysearch osteoclast differentiationsearch cellular response to ionizing radiationsearch toll-like receptor 4 signaling pathwaysearch regulation of transcription, DNA-templatedsearch apoptotic processsearch toll-like receptor signaling pathwaysearch cell surface receptor signaling pathwaysearch Ras protein signal transductionsearch gene expressionsearch TRIF-dependent toll-like receptor signaling pathwaysearch positive regulation of muscle cell differentiationsearch positive regulation of myoblast fusionsearch cellular response to DNA damage stimulussearch regulation of transcription from RNA polymerase II promotersearch positive regulation of protein import into nucleussearch skeletal muscle tissue developmentsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch glucose metabolic processsearch innate immune responsesearch lipopolysaccharide-mediated signaling pathwaysearch toll-like receptor 5 signaling pathwaysearch stress-induced premature senescencesearch positive regulation of reactive oxygen species metabolic processsearch positive regulation of myotube differentiationsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch striated muscle cell differentiationsearch positive regulation of blood vessel endothelial cell migrationsearch transcription, DNA-templatedsearch regulation of sequence-specific DNA binding transcription factor activitysearch activation of MAPK activitysearch myoblast differentiation involved in skeletal muscle regenerationsearch intracellular signal transductionsearch signal transductionsearch stress-activated MAPK cascadesearch neurotrophin TRK receptor signaling pathwaysearch cellular response to lipopolysaccharidesearch positive regulation of transcription from RNA polymerase II promotersearch negative regulation of canonical Wnt signaling pathwaysearch 3'-UTR-mediated mRNA stabilizationsearch movement of cell or subcellular componentsearch DNA damage checkpointsearch toll-like receptor 10 signaling pathwaysearch response to muramyl dipeptidesearch chondrocyte differentiationsearch cellular response to vascular endothelial growth factor stimulussearch organelle organizationsearch platelet activationsearch chemotaxissearch nucleoplasmsearch cytoplasmsearch cytosolsearch nucleussearch spindle polesearch extracellular vesicular exosomesearch mitochondrionsearch cellsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch