3gcu Summary


Human P38 MAP kinase in complex with RL48

The structure was published by Simard, J.R., Getlik, M., Grutter, C., et al., Wulfert, S., Rabiller, M., and Rauh, D., in 2009 in a paper entitled "Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Mitogen-activated protein kinase 14.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 94%
B Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (Q16539) transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch MAP kinase activitysearch protein serine/threonine kinase activitysearch ATP bindingsearch protein kinase activitysearch MAP kinase kinase activitysearch NFAT protein bindingsearch kinase activitysearch nucleotide bindingsearch transferase activitysearch cell morphogenesissearch positive regulation of myotube differentiationsearch neurotrophin TRK receptor signaling pathwaysearch toll-like receptor 9 signaling pathwaysearch lipopolysaccharide-mediated signaling pathwaysearch response to muramyl dipeptidesearch chondrocyte differentiationsearch DNA damage checkpointsearch positive regulation of myoblast differentiationsearch 3'-UTR-mediated mRNA stabilizationsearch positive regulation of myoblast fusionsearch toll-like receptor signaling pathwaysearch intracellular signal transductionsearch signal transductionsearch chemotaxissearch striated muscle cell differentiationsearch MyD88-dependent toll-like receptor signaling pathwaysearch cellular response to vascular endothelial growth factor stimulussearch skeletal muscle tissue developmentsearch protein phosphorylationsearch gene expressionsearch regulation of transcription, DNA-templatedsearch apoptotic processsearch peptidyl-serine phosphorylationsearch response to stresssearch glucose metabolic processsearch MyD88-independent toll-like receptor signaling pathwaysearch TRIF-dependent toll-like receptor signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch response to lipopolysaccharidesearch fatty acid oxidationsearch vascular endothelial growth factor receptor signaling pathwaysearch transcription, DNA-templatedsearch muscle cell differentiationsearch phosphorylationsearch signal transduction in response to DNA damagesearch toll-like receptor 4 signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch regulation of transcription from RNA polymerase II promotersearch toll-like receptor 5 signaling pathwaysearch Ras protein signal transductionsearch cell surface receptor signaling pathwaysearch innate immune responsesearch RNA metabolic processsearch myoblast differentiation involved in skeletal muscle regenerationsearch regulation of sequence-specific DNA binding transcription factor activitysearch toll-like receptor 2 signaling pathwaysearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch p38MAPK cascadesearch osteoclast differentiationsearch cellular response to ionizing radiationsearch cellular response to DNA damage stimulussearch positive regulation of erythrocyte differentiationsearch toll-like receptor 10 signaling pathwaysearch positive regulation of blood vessel endothelial cell migrationsearch platelet activationsearch angiogenesissearch activation of MAPK activitysearch negative regulation of canonical Wnt signaling pathwaysearch mRNA metabolic processsearch stress-activated MAPK cascadesearch positive regulation of reactive oxygen species metabolic processsearch stress-induced premature senescencesearch blood coagulationsearch toll-like receptor 3 signaling pathwaysearch cartilage condensationsearch cellular component movementsearch positive regulation of muscle cell differentiationsearch cellular response to lipopolysaccharidesearch toll-like receptor TLR1:TLR2 signaling pathwaysearch positive regulation of protein import into nucleussearch cellsearch cytosolsearch nucleoplasmsearch nucleussearch cytoplasmsearch mitochondrionsearch extracellular vesicular exosomesearch spindle polesearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch