3gcu Summary


Human P38 MAP kinase in complex with RL48

The structure was published by Simard, J.R., Getlik, M., Grutter, C., et al., Wulfert, S., Rabiller, M., and Rauh, D., in 2009 in a paper entitled "Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Mitogen-activated protein kinase 14.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 94%
B Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (Q16539) ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch MAP kinase kinase activitysearch protein bindingsearch MAP kinase activitysearch kinase activitysearch NFAT protein bindingsearch nucleotide bindingsearch protein serine/threonine kinase activitysearch transferase activitysearch protein phosphorylationsearch vascular endothelial growth factor receptor signaling pathwaysearch mitochondrion organizationsearch toll-like receptor 2 signaling pathwaysearch striated muscle cell differentiationsearch regulation of transcription from RNA polymerase II promotersearch chondrocyte differentiationsearch positive regulation of myoblast differentiationsearch muscle cell differentiationsearch peptidyl-serine phosphorylationsearch MyD88-independent toll-like receptor signaling pathwaysearch positive regulation of erythrocyte differentiationsearch response to muramyl dipeptidesearch MyD88-dependent toll-like receptor signaling pathwaysearch toll-like receptor 3 signaling pathwaysearch phosphorylationsearch signal transduction in response to DNA damagesearch toll-like receptor signaling pathwaysearch glucose metabolic processsearch cell surface receptor signaling pathwaysearch osteoclast differentiationsearch cellular response to ionizing radiationsearch toll-like receptor 9 signaling pathwaysearch apoptotic processsearch blood coagulationsearch Ras protein signal transductionsearch skeletal muscle tissue developmentsearch toll-like receptor 4 signaling pathwaysearch positive regulation of cyclase activitysearch gene expressionsearch TRIF-dependent toll-like receptor signaling pathwaysearch positive regulation of muscle cell differentiationsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch lipopolysaccharide-mediated signaling pathwaysearch positive regulation of blood vessel endothelial cell migrationsearch innate immune responsesearch cellular response to DNA damage stimulussearch DNA damage checkpointsearch regulation of sequence-specific DNA binding transcription factor activitysearch positive regulation of brown fat cell differentiationsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch angiogenesissearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of reactive oxygen species metabolic processsearch positive regulation of myotube differentiationsearch p38MAPK cascadesearch stress-induced premature senescencesearch regulation of cytokine production involved in inflammatory responsesearch toll-like receptor 5 signaling pathwaysearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch regulation of transcription, DNA-templatedsearch myoblast differentiation involved in skeletal muscle regenerationsearch movement of cell or subcellular componentsearch toll-like receptor 10 signaling pathwaysearch positive regulation of protein import into nucleussearch chemotaxissearch cellular response to vascular endothelial growth factor stimulussearch stress-activated MAPK cascadesearch cellular response to lipopolysaccharidesearch transcription, DNA-templatedsearch positive regulation of myoblast fusionsearch fatty acid oxidationsearch neurotrophin TRK receptor signaling pathwaysearch cell morphogenesissearch activation of MAPK activitysearch response to lipopolysaccharidesearch intracellular signal transductionsearch signal transductionsearch 3'-UTR-mediated mRNA stabilizationsearch organelle organizationsearch negative regulation of canonical Wnt signaling pathwaysearch cartilage condensationsearch platelet activationsearch nucleoplasmsearch spindle polesearch nucleussearch cytosolsearch mitochondrionsearch cytoplasmsearch extracellular exosomesearch cellsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch