3gcs Summary


Human P38 MAP kinase in complex with Sorafenib

The structure was published by Simard, J.R., Getlik, M., Grutter, C., et al., Wulfert, S., Rabiller, M., and Rauh, D., in 2009 in a paper entitled "Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 330 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 91%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) ATP bindingsearch MAP kinase activitysearch protein kinase activitysearch protein serine/threonine kinase activitysearch protein bindingsearch NFAT protein bindingsearch MAP kinase kinase activitysearch kinase activitysearch nucleotide bindingsearch transferase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch stress-induced premature senescencesearch apoptotic processsearch MyD88-independent toll-like receptor signaling pathwaysearch signal transductionsearch cellular response to lipopolysaccharidesearch chemotaxissearch RNA metabolic processsearch toll-like receptor 3 signaling pathwaysearch toll-like receptor 10 signaling pathwaysearch signal transduction in response to DNA damagesearch DNA damage checkpointsearch positive regulation of blood vessel endothelial cell migrationsearch cellular component movementsearch toll-like receptor 2 signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch skeletal muscle tissue developmentsearch regulation of transcription, DNA-templatedsearch striated muscle cell differentiationsearch toll-like receptor 5 signaling pathwaysearch regulation of transcription from RNA polymerase II promotersearch positive regulation of muscle cell differentiationsearch cartilage condensationsearch activation of MAPK activitysearch Ras protein signal transductionsearch fatty acid oxidationsearch response to muramyl dipeptidesearch positive regulation of reactive oxygen species metabolic processsearch toll-like receptor 4 signaling pathwaysearch vascular endothelial growth factor receptor signaling pathwaysearch positive regulation of myotube differentiationsearch response to lipopolysaccharidesearch peptidyl-serine phosphorylationsearch positive regulation of erythrocyte differentiationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch toll-like receptor signaling pathwaysearch gene expressionsearch angiogenesissearch positive regulation of myoblast differentiationsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch neurotrophin TRK receptor signaling pathwaysearch phosphorylationsearch cell surface receptor signaling pathwaysearch p38MAPK cascadesearch 3'-UTR-mediated mRNA stabilizationsearch innate immune responsesearch mRNA metabolic processsearch MyD88-dependent toll-like receptor signaling pathwaysearch positive regulation of protein import into nucleussearch cell morphogenesissearch muscle cell differentiationsearch chondrocyte differentiationsearch cellular response to ionizing radiationsearch cellular response to vascular endothelial growth factor stimulussearch lipopolysaccharide-mediated signaling pathwaysearch intracellular signal transductionsearch positive regulation of transcription from RNA polymerase II promotersearch TRIF-dependent toll-like receptor signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch transcription, DNA-templatedsearch stress-activated MAPK cascadesearch osteoclast differentiationsearch toll-like receptor 9 signaling pathwaysearch cellular response to DNA damage stimulussearch glucose metabolic processsearch myoblast differentiation involved in skeletal muscle regenerationsearch positive regulation of myoblast fusionsearch blood coagulationsearch platelet activationsearch negative regulation of canonical Wnt signaling pathwaysearch nucleoplasmsearch cytosolsearch nucleussearch mitochondrionsearch extracellular vesicular exosomesearch cytoplasmsearch spindle polesearch cellsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch