3gc9 Summary


The structure of p38beta C119S, C162S in complex with a dihydroquinazolinone inhibitor

The structure was published by Patel, S.B., Cameron, P.M., O'Keefe, S.J., et al., Liu, L., Becker, J.W., and Scapin, G., in 2009 in a paper entitled "The three-dimensional structure of MAP kinase p38beta: different features of the ATP-binding site in p38beta compared with p38alpha." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.05 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Mitogen-activated protein kinase 11.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 11 Q15759 (1-364) (MK11_HUMAN)search Homo sapienssearch 95% 370 91%
B Mitogen-activated protein kinase 11 Q15759 (1-364) (MK11_HUMAN)search Homo sapienssearch 95% 370 91%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q15759 (1 - 364) Mitogen-activated protein kinase 11 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (Q15759) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B (Q15759) intracellular signal transductionsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch positive regulation of muscle cell differentiationsearch mRNA metabolic processsearch toll-like receptor 3 signaling pathwaysearch phosphorylationsearch MyD88-independent toll-like receptor signaling pathwaysearch response to stresssearch toll-like receptor 4 signaling pathwaysearch MAPK cascadesearch protein phosphorylationsearch activation of MAPK activitysearch toll-like receptor 9 signaling pathwaysearch toll-like receptor signaling pathwaysearch Ras protein signal transductionsearch MyD88-dependent toll-like receptor signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch stress-activated MAPK cascadesearch transcription, DNA-templatedsearch regulation of transcription, DNA-templatedsearch gene expressionsearch toll-like receptor 5 signaling pathwaysearch TRIF-dependent toll-like receptor signaling pathwaysearch muscle cell differentiationsearch toll-like receptor 10 signaling pathwaysearch neurotrophin TRK receptor signaling pathwaysearch signal transductionsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch innate immune responsesearch toll-like receptor 2 signaling pathwaysearch RNA metabolic processsearch nucleoplasmsearch nucleussearch cytosolsearch cytoplasmsearch protein serine/threonine kinase activitysearch kinase activitysearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch MAP kinase activitysearch protein bindingsearch nucleotide bindingsearch transferase activitysearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch