3g9j Summary

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GR DNA binding domain:Pal, 18bp complex-36

The structure was published by Meijsing, S.H., Pufall, M.A., So, A.Y., Bates, D.L., Chen, L., and Yamamoto, K.R., in 2009 in a paper entitled "DNA binding site sequence directs glucocorticoid receptor structure and activity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.32 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely DNA (5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*AP*AP*AP*TP*GP*TP*TP*CP*TP*G)-3'), DNA (5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*TP*TP*TP*TP*GP*TP*TP*CP*TP*G)-3'), and Glucocorticoid receptor.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucocorticoid receptor P06536 (440-525) (GCR_RAT)search Rattus norvegicussearch < 90% 90 87%
B Glucocorticoid receptor P06536 (440-525) (GCR_RAT)search Rattus norvegicussearch < 90% 90 87%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P06536 (440 - 525) Glucocorticoid receptor Rattus norvegicus

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Erythroid Transcription Factor GATA-1, subunit Asearch Zinc finger, C4 type (two domains)search

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P06536) regulation of transcription, DNA-templatedsearch zinc ion bindingsearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch steroid hormone receptor activitysearch sequence-specific DNA bindingsearch calcitriol receptor activitysearch nucleussearch

Chain InterPro annotation
A, B Zinc finger, nuclear hormone receptor-typesearch Zinc finger, NHR/GATA-typesearch