3g90 Summary

pdbe.org/3g90
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JNK-3 bound to (Z)-5-fluoro-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)indolin-2-one

The structure was published by Cao, J., Gao, H., Bemis, G., et al., Xie, X., Jacobs, M., and Green, J., in 2009 in a paper entitled "Structure-based design and parallel synthesis of N-benzyl isatin oximes as JNK3 MAP kinase inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 10. This molecule has the UniProt identifier P53779 (MK10_HUMAN)search. The sample contained 365 residues which is < 90% of the natural sequence. Out of 365 residues 344 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
X Mitogen-activated protein kinase 10 P53779 (40-402) (MK10_HUMAN)search Homo sapienssearch 91% 365 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P53779 (40 - 402) Mitogen-activated protein kinase 10 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
X (P53779) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
X (P53779) ATP bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch MAP kinase activitysearch protein kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
X Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Serine/threonine-protein kinase, active sitesearch Mitogen-activated protein (MAP) kinase, JNKsearch Protein kinase-like domainsearch