3g8o Summary


PDB entry 3g8o (supersedes 3g8n)

Progesterone Receptor with bound Pyrrolidine 1

The structure was published by Thompson, S.K., Washburn, D.G., Frazee, J.S., et al., Duraiswami, C., Bray, J.D., and Laping, N.J., in 2009 in a paper entitled "Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Progesterone receptor.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Progesterone receptor P06401 (673-933) (PRGR_HUMAN)search Homo sapienssearch < 90% 263 95%
B Progesterone receptor P06401 (673-933) (PRGR_HUMAN)search Homo sapienssearch < 90% 263 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P06401 (673 - 933) Progesterone receptor Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P06401) regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch DNA bindingsearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch nucleussearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch