3g6q Summary


GR DNA binding domain:FKBP5 binding site complex-9

The structure was published by Meijsing, S.H., Pufall, M.A., So, A.Y., Bates, D.L., Chen, L., and Yamamoto, K.R., in 2009 in a paper entitled "DNA binding site sequence directs glucocorticoid receptor structure and activity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.26 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Glucocorticoid receptor, DNA (5'-D(*TP*AP*GP*AP*AP*CP*AP*GP*GP*GP*TP*GP*TP*TP*CP*T)-3'), and DNA (5'-D(*AP*AP*GP*AP*AP*CP*AP*CP*CP*CP*TP*GP*TP*TP*CP*T)-3').

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
B Glucocorticoid receptor P06536 (440-525) (GCR_RAT)search Rattus norvegicussearch < 90% 90 86%
A Glucocorticoid receptor P06536 (440-525) (GCR_RAT)search Rattus norvegicussearch < 90% 90 86%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P06536 (440 - 525) Glucocorticoid receptor Rattus norvegicus

Chain Structural classification (CATH) Sequence family (Pfam)
B, A Erythroid Transcription Factor GATA-1, subunit Asearch Zinc finger, C4 type (two domains)search

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
B, A (P06536) sequence-specific DNA binding transcription factor activitysearch calcitriol receptor activitysearch zinc ion bindingsearch DNA bindingsearch sequence-specific DNA bindingsearch steroid hormone receptor activitysearch regulation of transcription, DNA-templatedsearch nucleussearch

Chain InterPro annotation
B, A Zinc finger, nuclear hormone receptor-typesearch Zinc finger, NHR/GATA-typesearch