3g6h Summary details

pdbe.org/3g6h/summary_details
spacer Src Thr338Ile inhibited in the DFG-Asp-Out conformation
Summary
Header TRANSFERASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.35 Å, R-factor: 22.781%, Free R-factor: 28.268%, Spacegroup: P 1
Released 24/03/2009, deposition: 06/02/2009, last revision: 24/03/2009
Authors Seeliger, M.A.search; Ranjitkar, P.search; Kasap, C.search; Shan, Y.search; Shaw, D.E.search; Shah, N.P.search; Kuriyan, J.search; Maly, D.J.search
Primary citation Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations
CANCER RES.search vol:69, pag:2384-2392 (2009) [PubMed 19276351 ]search
Keywords Cancersearch, imatinib resistancesearch, DSA compoundssearch, kinasesearch, DFG-Asp-Outsearch, ATP-bindingsearch, Lipoproteinsearch, Myristatesearch, Nucleotide-bindingsearch, Phosphoproteinsearch, Proto-oncogenesearch, SH2 domainsearch, SH3 domainsearch, Transferasesearch, Tyrosine-protein kinasesearch
EC 2.7.10.2 ExPASy BRENDA search (B A)
Organism Gallus gallus(chicken) 9031search(A B)
UniProt P00523search (A B)
Solvent A, B
Related entries 3g6g
Polymers
Chain Id Name Type UniProt Residues in sample sequence % of sample sequence observed
A, B Proto-oncogene tyrosine-protein kinase Src Protein P00523 (SRC_CHICK)search
286 93%
Heterogens
Chain Id Name Ligands
B N-{4-METHYL-3-[(3-{4-[(3,4,5-TRIMETHOXYPHENYL)AMINO]-1,3,5-TRIAZIN-2-YL}PYRIDIN-2-YL)AMINO]PHENYL}-3-(TRIFLUOROMETHYL)BENZAMIDE G6H search
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