3g6h Summary

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Src Thr338Ile inhibited in the DFG-Asp-Out conformation

The structure was published by Seeliger, M.A., Ranjitkar, P., Kasap, C., et al., Shah, N.P., Kuriyan, J., and Maly, D.J., in 2009 in a paper entitled "Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.35 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Proto-oncogene tyrosine-protein kinase Src.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Proto-oncogene tyrosine-protein kinase Src P00523 (251-533) (SRC_CHICK)search Gallus gallussearch < 90% 286 93%
B Proto-oncogene tyrosine-protein kinase Src P00523 (251-533) (SRC_CHICK)search Gallus gallussearch < 90% 286 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00523 (251 - 533) Proto-oncogene tyrosine-protein kinase Src Gallus gallus

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P00523) transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch protein tyrosine kinase activitysearch ATP bindingsearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch