3g6g Summary

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Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations

The structure was published by Seeliger, M.A., Ranjitkar, P., Kasap, C., et al., Shah, N.P., Kuriyan, J., and Maly, D.J., in 2009 in a paper entitled "Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.31 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Proto-oncogene tyrosine-protein kinase Src.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Proto-oncogene tyrosine-protein kinase Src P00523 (251-533) (SRC_CHICK)search Gallus gallussearch < 90% 286 92%
B Proto-oncogene tyrosine-protein kinase Src P00523 (251-533) (SRC_CHICK)search Gallus gallussearch < 90% 286 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00523 (251 - 533) Proto-oncogene tyrosine-protein kinase Src Gallus gallus

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P00523) protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein tyrosine kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch