3g6d Summary

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Crystal structure of the complex between CNTO607 Fab and IL-13

The structure was published by Teplyakov, A., Obmolova, G., Wu, S.J., et al., Kang, J., O'Neil, K., and Gilliland, G.L., in 2009 in a paper entitled "Epitope mapping of anti-interleukin-13 neutralizing antibody CNTO607." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.2 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely CNTO607 Fab Light chain, CNTO607 Fab Heavy chain, and Interleukin-13.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
L CNTO607 Fab Light chain Not available
Homo sapienssearch Not available 213 98%
H CNTO607 Fab Heavy chain Not available
Homo sapienssearch Not available 229 97%
A Interleukin-13 P35225 (35-146) (IL13_HUMAN)search Homo sapienssearch 92% 113 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35225 (35 - 146) Interleukin-13 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
L
H Immunoglobulinssearch
A (P35225) Growth Hormone; Chain: A;search PF03487: Interleukin-13search

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P35225) interleukin-13 receptor bindingsearch cytokine receptor bindingsearch protein bindingsearch cytokine activitysearch cellular component movementsearch positive regulation of B cell proliferationsearch regulation of proton transportsearch immune responsesearch cellular response to mechanical stimulussearch positive regulation of tyrosine phosphorylation of Stat6 proteinsearch positive regulation of smooth muscle cell proliferationsearch positive regulation of release of sequestered calcium ion into cytosolsearch negative regulation of transforming growth factor beta productionsearch inflammatory responsesearch positive regulation of macrophage activationsearch response to ethanolsearch positive regulation of ion transportsearch positive regulation of immunoglobulin productionsearch cellular response to cytokine stimulussearch positive regulation of pancreatic stellate cell proliferationsearch response to nicotinesearch negative regulation of lung ciliated cell differentiationsearch positive regulation of protein secretionsearch signal transductionsearch positive regulation of lung goblet cell differentiationsearch response to mechanical stimulussearch positive regulation of connective tissue growth factor productionsearch cell-cell signalingsearch response to lipopolysaccharidesearch extracellular spacesearch extracellular regionsearch external side of plasma membranesearch cytoplasmsearch

Chain InterPro annotation
L Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin V-set, subgroupsearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
H Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin V-set, subgroupsearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
A Interleukin-4/interleukin-13search Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch Interleukin-4/interleukin-13, conserved sitesearch Interleukin-13search