3g5v Summary

pdbe.org/3g5v
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Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR

The structure was published by Garrett, T.P.J., Burgess, A.W., Gan, H.K., et al., Yao, S., Scott, A.M., and Johns, T.G., in 2009 in a paper entitled "Antibodies specifically targeting a locally misfolded region of tumor associated EGFR" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.001 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely 806 light chain, 808 heavy chain, and Epidermal Growth Factor Receptor peptide.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A 806 light chain Not available
Mus musculussearch Not available 212 100%
B 808 heavy chain Not available
Mus musculussearch Not available 213 93%
C Epidermal Growth Factor Receptor peptide P00533 (311-326) (EGFR_HUMAN)search Homo sapienssearch < 90% 16 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00533 (311 - 326) Epidermal Growth Factor Receptor peptide

Chain Structural classification (CATH) Sequence family (Pfam)
A Immunoglobulinssearch
B Immunoglobulinssearch
C Furin-like cysteine rich regionsearch
Chain InterPro annotation
A Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin V-set, subgroupsearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
B Immunoglobulin V-set, subgroupsearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
C