3g51 Summary


Structural diversity of the active conformation of the N-terminal kinase domain of p90 ribosomal S6 kinase 2

The structure was published by Malakhova, M., Kurinov, I., Liu, K., et al., Steinman, V., Bode, A.M., and Dong, Z., in 2009 in a paper entitled "Structural diversity of the active N-terminal kinase domain of p90 ribosomal S6 kinase 2" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Ribosomal protein S6 kinase alpha-3. This molecule has the UniProt identifier P18654 (KS6A3_MOUSE)search. The sample contained 325 residues which is < 90% of the natural sequence. Out of 325 residues 280 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Ribosomal protein S6 kinase alpha-3 P18654 (44-367) (KS6A3_MOUSE)search Mus musculussearch < 90% 325 86%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P18654 (44 - 367) Ribosomal protein S6 kinase alpha-3 Mus musculus

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch, Protein kinase C terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (P18654) protein kinase activitysearch protein serine/threonine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch