3g2f Summary


Crystal structure of the kinase domain of bone morphogenetic protein receptor type II (BMPR2) at 2.35 A resolution

A publication describing this structure is not available. The depositing authors are Chaikuad, A.search; Thangaratnarajah, C.search; Roos, A.K.search; Filippakopoulos, P.search; Salah, E.search; Phillips, C.search; Keates, T.search; Fedorov, O.search; Chalk, R.search; Petrie, K.search; Pike, A.C.W.search; Von Delft, F.search; Arrowsmith, C.H.search; Edwards, A.M.search; Weigelt, J.search; Bountra, C.search; Knapp, S.search; Bullock, A.search; Structural Genomics Consortium (SGC)search

This crystal structure was determined using X-ray diffraction at a resolution of 2.35 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Bone morphogenetic protein receptor type-2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Bone morphogenetic protein receptor type-2 Q13873 (189-517) (BMPR2_HUMAN)search Homo sapienssearch < 90% 336 90%
B Bone morphogenetic protein receptor type-2 Q13873 (189-517) (BMPR2_HUMAN)search Homo sapienssearch < 90% 336 90%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q13873 (189 - 517) Bone morphogenetic protein receptor type-2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (Q13873) receptor signaling protein serine/threonine kinase activitysearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch membranesearch

Chain InterPro annotation
A, B Ser/Thr protein kinase, TGFB receptorsearch Protein kinase domainsearch Protein kinase-like domainsearch Bone morphogenetic protein receptor type-2search Protein kinase, ATP binding sitesearch