3g0e Summary

pdbe.org/3g0e
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KIT kinase domain in complex with sunitinib

The structure was published by Gajiwala, K.S., Wu, J.C., Christensen, J., et al., Marshall, A.G., Zhang, H.M., and Demetri, G.D., in 2009 in a paper entitled "KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mast/stem cell growth factor receptor. This molecule has the UniProt identifier P10721 (KIT_HUMAN)search. The sample contained 336 residues which is < 90% of the natural sequence. Out of 336 residues 332 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mast/stem cell growth factor receptor P10721 (544-693) (KIT_HUMAN)search ,
P10721 (754-935) (KIT_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch
< 90% ,
< 90%
336 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P10721 (544 - 693) Mast/stem cell growth factor receptor Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P10721) transmembrane receptor protein tyrosine kinase activitysearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein tyrosine kinase activitysearch membranesearch protein phosphorylationsearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, receptor class III, conserved sitesearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch