KIT kinase domain in complex with sunitinib
The structure was published by Gajiwala, K.S., Wu, J.C., Christensen, J., et al., Marshall, A.G., Zhang, H.M., and Demetri, G.D., in 2009 in a paper entitled "KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2009.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Mast/stem cell growth factor receptor. This molecule has the UniProt identifier P10721 (KIT_HUMAN). The sample contained 336 residues which is < 90% of the natural sequence. Out of 336 residues 332 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: