3fz1 Summary


Crystal structure of a benzthiophene inhibitor bound to human Cyclin-dependent Kinase-2 (CDK-2)

The structure was published by Anderson, D.R., Meyers, M.J., Kurumbail, R.G., et al., Mahoney, M.W., Mourey, R.J., and Parikh, M.D., in 2009 in a paper entitled "Benzothiophene inhibitors of MK2. Part 2: improvements in kinase selectivity and cell potency." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Cell division protein kinase 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 283 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cell division protein kinase 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) Cell division protein kinase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P24941) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch protein bindingsearch nucleotide bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch histone kinase activitysearch kinase activitysearch cyclin bindingsearch transferase activitysearch metal ion bindingsearch protein phosphorylationsearch meiotic nuclear divisionsearch DNA replicationsearch mitotic nuclear divisionsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch centrosome duplicationsearch phosphorylationsearch cell cyclesearch regulation of gene silencingsearch positive regulation of transcription, DNA-templatedsearch DNA repairsearch positive regulation of DNA-dependent DNA replication initiationsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch mitotic G2 phasesearch G2/M transition of mitotic cell cyclesearch potassium ion transportsearch cellular response to DNA damage stimulussearch mitotic cell cyclesearch cell divisionsearch blood coagulationsearch histone phosphorylationsearch Ras protein signal transductionsearch positive regulation of cell proliferationsearch cellular response to nitric oxidesearch G1/S transition of mitotic cell cyclesearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch mitotic G1 DNA damage checkpointsearch nucleoplasmsearch endosomesearch cytoskeletonsearch cytosolsearch cyclin-dependent protein kinase holoenzyme complexsearch nucleussearch microtubule organizing centersearch chromosome, telomeric regionsearch condensed chromosomesearch cytoplasmsearch Cajal bodysearch X chromosomesearch transcription factor complexsearch centrosomesearch Y chromosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch