3fy2 Summary


Human EphA3 Kinase and Juxtamembrane Region Bound to Substrate KQWDNYEFIW

The structure was published by Davis, T.L., Walker, J.R., Allali-Hassani, A., Parker, S.A., Turk, B.E., and Dhe-Paganon, S., in 2009 in a paper entitled "Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Ephrin type-A receptor 3 and peptide substrate.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Ephrin type-A receptor 3 P29320 (577-947) (EPHA3_HUMAN)search Homo sapienssearch < 90% 371 76%
B peptide substrate Not available
Synthetic Not available 10 80%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P29320 (577 - 947) Ephrin type-A receptor 3 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search SAM domain (Sterile alpha motif)search, Protein tyrosine kinasesearch, Ephrin type-A receptor 2 transmembrane domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (P29320) protein kinase activitysearch protein tyrosine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch Ephrin receptor, transmembrane domainsearch