3fw3 Summary


Crystal Structure of soluble domain of CA4 in complex with Dorzolamide

The structure was published by Vernier, W., Chong, W., Rewolinski, D., et al., Nukui, S., Ornelas, M., and Reyner, E., in 2010 in a paper entitled "Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: structure-based drug design, synthesis, and biological evaluation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.72 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Carbonic anhydrase 4.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 4 P22748 (19-284) (CAH4_HUMAN)search Homo sapienssearch 90% 266 95%
B Carbonic anhydrase 4 P22748 (19-284) (CAH4_HUMAN)search Homo sapienssearch 90% 266 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P22748 (19 - 284) Carbonic anhydrase 4 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P22748) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P22748) carbonate dehydratase activitysearch metal ion bindingsearch protein bindingsearch zinc ion bindingsearch lyase activitysearch one-carbon metabolic processsearch small molecule metabolic processsearch response to drugsearch organ developmentsearch bicarbonate transportsearch response to steroid hormonesearch plasma membranesearch anchored component of external side of plasma membranesearch extracellular vesicular exosomesearch sarcoplasmic reticulumsearch trans-Golgi networksearch apical plasma membranesearch membranesearch secretory granule membranesearch sarcolemmasearch cell surfacesearch endoplasmic reticulum-Golgi intermediate compartmentsearch Golgi apparatussearch rough endoplasmic reticulumsearch perinuclear region of cytoplasmsearch transport vesicle membranesearch basolateral plasma membranesearch anchored component of membranesearch brush border membranesearch anchored component of plasma membranesearch

Chain InterPro annotation
A, B Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase, CA4search Carbonic anhydrase, alpha-classsearch