3fv8 Summary

pdbe.org/3fv8
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JNK3 bound to piperazine amide inhibitor, SR2774.

The structure was published by Shin, Y., Chen, W., Habel, J., et al., Vojkovsky, T., LoGrasso, P., and Kamenecka, T.M., in 2009 in a paper entitled "Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.28 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 10. This molecule has the UniProt identifier P53779 (MK10_HUMAN)search. The sample contained 355 residues which is < 90% of the natural sequence. Out of 355 residues 333 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 10 P53779 (39-366) (MK10_HUMAN)search ,
P53779 (381-402) (MK10_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch
91% ,
91%
355 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P53779 (39 - 366) Mitogen-activated protein kinase 10 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P53779) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A (P53779) protein phosphorylationsearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch MAP kinase activitysearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Serine/threonine-protein kinase, active sitesearch Mitogen-activated protein (MAP) kinase, JNKsearch Protein kinase-like domainsearch