3fsk Summary


P38 kinase crystal structure in complex with RO6257

A publication describing this structure is not available. The depositing authors are Kuglstatter, A.search; Bertrand, J.search; Takahara, P.search; Villasenor, A.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 372 residues which is 100% of the natural sequence. Out of 372 residues 341 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 372 91%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) protein bindingsearch protein kinase activitysearch NFAT protein bindingsearch MAP kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch transferase activitysearch kinase activitysearch protein serine/threonine kinase activitysearch nucleotide bindingsearch MAP kinase kinase activitysearch myoblast differentiation involved in skeletal muscle regenerationsearch regulation of transcription, DNA-templatedsearch regulation of transcription from RNA polymerase II promotersearch lipopolysaccharide-mediated signaling pathwaysearch chondrocyte differentiationsearch cartilage condensationsearch response to muramyl dipeptidesearch toll-like receptor 4 signaling pathwaysearch positive regulation of myoblast fusionsearch positive regulation of protein import into nucleussearch toll-like receptor TLR6:TLR2 signaling pathwaysearch toll-like receptor 9 signaling pathwaysearch cellular response to lipopolysaccharidesearch MyD88-independent toll-like receptor signaling pathwaysearch DNA damage checkpointsearch MyD88-dependent toll-like receptor signaling pathwaysearch protein phosphorylationsearch apoptotic processsearch angiogenesissearch positive regulation of myoblast differentiationsearch positive regulation of transcription from RNA polymerase II promotersearch toll-like receptor 10 signaling pathwaysearch peptidyl-serine phosphorylationsearch muscle cell differentiationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch glucose metabolic processsearch RNA metabolic processsearch cellular response to DNA damage stimulussearch innate immune responsesearch osteoclast differentiationsearch fatty acid oxidationsearch cellular response to vascular endothelial growth factor stimulussearch chemotaxissearch blood coagulationsearch negative regulation of canonical Wnt signaling pathwaysearch positive regulation of myotube differentiationsearch positive regulation of blood vessel endothelial cell migrationsearch phosphorylationsearch response to lipopolysaccharidesearch p38MAPK cascadesearch signal transductionsearch intracellular signal transductionsearch toll-like receptor 5 signaling pathwaysearch TRIF-dependent toll-like receptor signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch positive regulation of erythrocyte differentiationsearch vascular endothelial growth factor receptor signaling pathwaysearch cell surface receptor signaling pathwaysearch activation of MAPK activitysearch neurotrophin TRK receptor signaling pathwaysearch toll-like receptor signaling pathwaysearch gene expressionsearch platelet activationsearch response to stresssearch skeletal muscle tissue developmentsearch mRNA metabolic processsearch signal transduction in response to DNA damagesearch striated muscle cell differentiationsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch Ras protein signal transductionsearch toll-like receptor 2 signaling pathwaysearch cellular response to ionizing radiationsearch cellular component movementsearch positive regulation of muscle cell differentiationsearch cell morphogenesissearch transcription, DNA-templatedsearch stress-activated MAPK cascadesearch toll-like receptor 3 signaling pathwaysearch 3'-UTR-mediated mRNA stabilizationsearch stress-induced premature senescencesearch positive regulation of reactive oxygen species metabolic processsearch nucleoplasmsearch cytoplasmsearch cytosolsearch cellsearch mitochondrionsearch extracellular vesicular exosomesearch spindle polesearch nucleussearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch