3fsf Summary


P38 kinase crystal structure in complex with 3-(2,6-Dichloro-phenyl)-7-[4-(2-diethylamino-ethoxy)-phenylamino]-1-methyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one

A publication describing this structure is not available. The depositing authors are Kuglstatter, A.search; Bertrand, J.search; Lovejoy, B.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 372 residues which is 100% of the natural sequence. Out of 372 residues 339 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 372 91%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) ATP bindingsearch MAP kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch protein kinase activitysearch kinase activitysearch MAP kinase kinase activitysearch NFAT protein bindingsearch transferase activitysearch protein serine/threonine kinase activitysearch nucleotide bindingsearch protein phosphorylationsearch MyD88-dependent toll-like receptor signaling pathwaysearch toll-like receptor 3 signaling pathwaysearch glucose metabolic processsearch toll-like receptor 10 signaling pathwaysearch positive regulation of myoblast fusionsearch fatty acid oxidationsearch regulation of transcription, DNA-templatedsearch response to stresssearch positive regulation of myoblast differentiationsearch TRIF-dependent toll-like receptor signaling pathwaysearch positive regulation of myotube differentiationsearch 3'-UTR-mediated mRNA stabilizationsearch cell surface receptor signaling pathwaysearch cellular response to lipopolysaccharidesearch osteoclast differentiationsearch intracellular signal transductionsearch toll-like receptor 5 signaling pathwaysearch stress-induced premature senescencesearch cellular response to ionizing radiationsearch cellular response to DNA damage stimulussearch signal transduction in response to DNA damagesearch neurotrophin TRK receptor signaling pathwaysearch Ras protein signal transductionsearch peptidyl-serine phosphorylationsearch toll-like receptor 2 signaling pathwaysearch positive regulation of erythrocyte differentiationsearch innate immune responsesearch MyD88-independent toll-like receptor signaling pathwaysearch signal transductionsearch MAPK cascadesearch skeletal muscle tissue developmentsearch RNA metabolic processsearch DNA damage checkpointsearch toll-like receptor signaling pathwaysearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch apoptotic processsearch phosphorylationsearch blood coagulationsearch toll-like receptor 9 signaling pathwaysearch cellular component movementsearch cell morphogenesissearch positive regulation of blood vessel endothelial cell migrationsearch chondrocyte differentiationsearch vascular endothelial growth factor receptor signaling pathwaysearch positive regulation of reactive oxygen species metabolic processsearch cartilage condensationsearch striated muscle cell differentiationsearch cellular response to vascular endothelial growth factor stimulussearch toll-like receptor TLR1:TLR2 signaling pathwaysearch activation of MAPK activitysearch angiogenesissearch transcription, DNA-templatedsearch toll-like receptor 4 signaling pathwaysearch chemotaxissearch lipopolysaccharide-mediated signaling pathwaysearch regulation of transcription from RNA polymerase II promotersearch positive regulation of muscle cell differentiationsearch stress-activated MAPK cascadesearch response to lipopolysaccharidesearch mRNA metabolic processsearch positive regulation of protein import into nucleussearch negative regulation of canonical Wnt signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch p38MAPK cascadesearch gene expressionsearch regulation of sequence-specific DNA binding transcription factor activitysearch response to muramyl dipeptidesearch muscle cell differentiationsearch platelet activationsearch nucleoplasmsearch cytoplasmsearch extracellular vesicular exosomesearch cytosolsearch nucleussearch mitochondrionsearch cellsearch spindle polesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch