› 3fsf

X-ray diffraction
2.1Å resolution

P38 kinase crystal structure in complex with 3-(2,6-Dichloro-phenyl)-7-[4-(2-diethylamino-ethoxy)-phenylamino]-1-methyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one

Released:
DOI: 10.2210/pdb3fsf/pdb
PDB entry 3fsf coloured by chain, front view.
PDB entry 3fsf coloured by chain, side view.
PDB entry 3fsf coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kuglstatter A, Bertrand J, Lovejoy B

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172487 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 14 Chain: A
Molecule details ›
Chain: A
Length: 372 amino acids
Theoretical weight: 42.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16539 (Residues: 1-360; Coverage: 100%)
Gene names: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, SAPK2A
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand FSS 1 x FSS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P212121
Unit cell:
a: 45.202Å b: 86.402Å c: 124.158Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.225 0.259
Expression system: Escherichia coli

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