3fs1 Summary


Crystal structure of HNF4a LBD in complex with the ligand and the coactivator PGC-1a fragment

The structure was published by Rha, G.B., Wu, G., Shoelson, S.E., and Chi, Y.I., in 2009 in a paper entitled "Multiple binding modes between HNF4alpha and the LXXLL motifs of PGC-1alpha lead to full activation" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hepatocyte nuclear factor 4-alpha and PPARgamma Coactivator-1a (PGC-1a).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hepatocyte nuclear factor 4-alpha P41235 (148-377) (HNF4A_HUMAN)search Homo sapienssearch < 90% 230 100%
B PPARgamma Coactivator-1a (PGC-1a) Not available
Homo sapienssearch Not available 9 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P41235 (148 - 377) Hepatocyte nuclear factor 4-alpha Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P41235) regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch steroid hormone receptor activitysearch ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitysearch nucleussearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Transcription factor COUPsearch Nuclear hormone receptor, ligand-bindingsearch