Crystal structure of spleen tyrosine kinase complexed with R406
The structure was published by Villasenor, A.G., Kondru, R., Ho, H., et al., Barnett, J.W., Browner, M.F., and Kuglstatter, A., in 2009 in a paper entitled "Structural insights for design of potent spleen tyrosine kinase inhibitors from crystallographic analysis of three inhibitor complexes." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2009.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Tyrosine-protein kinase SYK. This molecule has the UniProt identifier P43405 (KSYK_HUMAN). The sample contained 291 residues which is < 90% of the natural sequence. Out of 291 residues 268 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: