3fpq Summary


PDB entry 3fpq (supersedes 1t4h)

Crystal structure of the kinase domain of WNK1

The structure was published by Min, X., Lee, B.H., Cobb, M.H., and Goldsmith, E.J., in 2004 in a paper entitled "Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Serine/threonine-protein kinase WNK1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Serine/threonine-protein kinase WNK1 Q9JIH7 (194-483) (WNK1_RAT)search Rattus norvegicussearch < 90% 290 93%
B Serine/threonine-protein kinase WNK1 Q9JIH7 (194-483) (WNK1_RAT)search Rattus norvegicussearch < 90% 290 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9JIH7 (194 - 483) Serine/threonine-protein kinase WNK1 Rattus norvegicus

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (Q9JIH7) protein phosphorylationsearch regulation of signal transductionsearch protein kinase activitysearch ATP bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch