3fpq Summary

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PDB entry 3fpq (supersedes 1t4h)

Crystal structure of the kinase domain of WNK1

The structure was published by Min, X., Lee, B.H., Cobb, M.H., and Goldsmith, E.J., in 2004 in a paper entitled "Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Serine/threonine-protein kinase WNK1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Serine/threonine-protein kinase WNK1 Q9JIH7 (194-483) (WNK1_RAT)search Rattus norvegicussearch < 90% 290 93%
B Serine/threonine-protein kinase WNK1 Q9JIH7 (194-483) (WNK1_RAT)search Rattus norvegicussearch < 90% 290 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9JIH7 (194 - 483) Serine/threonine-protein kinase WNK1 Rattus norvegicus

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (Q9JIH7) protein phosphorylationsearch regulation of signal transductionsearch protein kinase activitysearch ATP bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch