3fmm Summary


P38 kinase crystal structure in complex with RO6226

A publication describing this structure is not available. The depositing authors are Kuglstatter, A.search; Ghate, M.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 372 residues which is 100% of the natural sequence. Out of 372 residues 346 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 372 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q16539) protein phosphorylationsearch TRIF-dependent toll-like receptor signaling pathwaysearch cellular response to ionizing radiationsearch apoptotic processsearch 3'-UTR-mediated mRNA stabilizationsearch transcription, DNA-templatedsearch cartilage condensationsearch cell surface receptor signaling pathwaysearch positive regulation of myoblast fusionsearch peptidyl-serine phosphorylationsearch regulation of transcription, DNA-templatedsearch muscle cell differentiationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch intracellular signal transductionsearch skeletal muscle tissue developmentsearch p38MAPK cascadesearch fatty acid oxidationsearch RNA metabolic processsearch positive regulation of blood vessel endothelial cell migrationsearch innate immune responsesearch positive regulation of protein import into nucleussearch signal transductionsearch glucose metabolic processsearch positive regulation of myotube differentiationsearch gene expressionsearch MyD88-independent toll-like receptor signaling pathwaysearch toll-like receptor 2 signaling pathwaysearch angiogenesissearch chondrocyte differentiationsearch Ras protein signal transductionsearch positive regulation of myoblast differentiationsearch cell morphogenesissearch toll-like receptor 4 signaling pathwaysearch osteoclast differentiationsearch signal transduction in response to DNA damagesearch MyD88-dependent toll-like receptor signaling pathwaysearch cellular response to vascular endothelial growth factor stimulussearch regulation of sequence-specific DNA binding transcription factor activitysearch vascular endothelial growth factor receptor signaling pathwaysearch positive regulation of reactive oxygen species metabolic processsearch toll-like receptor 9 signaling pathwaysearch stress-activated MAPK cascadesearch activation of MAPK activitysearch stress-induced premature senescencesearch toll-like receptor TLR6:TLR2 signaling pathwaysearch cellular response to DNA damage stimulussearch neurotrophin TRK receptor signaling pathwaysearch response to stresssearch lipopolysaccharide-mediated signaling pathwaysearch positive regulation of muscle cell differentiationsearch toll-like receptor signaling pathwaysearch regulation of transcription from RNA polymerase II promotersearch toll-like receptor 10 signaling pathwaysearch positive regulation of erythrocyte differentiationsearch response to lipopolysaccharidesearch blood coagulationsearch myoblast differentiation involved in skeletal muscle regenerationsearch toll-like receptor 5 signaling pathwaysearch cellular component movementsearch toll-like receptor 3 signaling pathwaysearch negative regulation of canonical Wnt signaling pathwaysearch DNA damage checkpointsearch response to muramyl dipeptidesearch mRNA metabolic processsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch phosphorylationsearch platelet activationsearch chemotaxissearch striated muscle cell differentiationsearch positive regulation of transcription from RNA polymerase II promotersearch cellular response to lipopolysaccharidesearch MAP kinase activitysearch protein bindingsearch kinase activitysearch nucleotide bindingsearch protein serine/threonine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch MAP kinase kinase activitysearch NFAT protein bindingsearch transferase activitysearch nucleoplasmsearch cytosolsearch cytoplasmsearch extracellular vesicular exosomesearch spindle polesearch nucleussearch mitochondrionsearch cellsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch