3fmk Summary


P38 kinase crystal structure in complex with 6-(2,4-Difluoro-phenoxy)-8-methyl-2-((S)-1-methyl-2-tetrazol-2-yl-ethylamino)-8H-pyrido[2,3-d]pyrimidin-7-one

A publication describing this structure is not available. The depositing authors are Kuglstatter, A.search; Ghate, M.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 372 residues which is 100% of the natural sequence. Out of 372 residues 346 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 372 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) protein bindingsearch NFAT protein bindingsearch nucleotide bindingsearch protein serine/threonine kinase activitysearch transferase activitysearch MAP kinase activitysearch protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch MAP kinase kinase activitysearch kinase activitysearch innate immune responsesearch RNA metabolic processsearch regulation of transcription, DNA-templatedsearch gene expressionsearch stress-activated MAPK cascadesearch negative regulation of canonical Wnt signaling pathwaysearch toll-like receptor 2 signaling pathwaysearch osteoclast differentiationsearch positive regulation of reactive oxygen species metabolic processsearch MyD88-independent toll-like receptor signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch peptidyl-serine phosphorylationsearch cellular response to DNA damage stimulussearch positive regulation of myoblast fusionsearch positive regulation of myotube differentiationsearch cell surface receptor signaling pathwaysearch toll-like receptor 4 signaling pathwaysearch TRIF-dependent toll-like receptor signaling pathwaysearch positive regulation of erythrocyte differentiationsearch positive regulation of transcription from RNA polymerase II promotersearch angiogenesissearch cartilage condensationsearch blood coagulationsearch protein phosphorylationsearch platelet activationsearch cell morphogenesissearch response to lipopolysaccharidesearch mRNA metabolic processsearch toll-like receptor 10 signaling pathwaysearch transcription, DNA-templatedsearch striated muscle cell differentiationsearch signal transductionsearch positive regulation of blood vessel endothelial cell migrationsearch toll-like receptor 3 signaling pathwaysearch activation of MAPK activitysearch toll-like receptor signaling pathwaysearch stress-induced premature senescencesearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch positive regulation of myoblast differentiationsearch skeletal muscle tissue developmentsearch response to stresssearch intracellular signal transductionsearch vascular endothelial growth factor receptor signaling pathwaysearch positive regulation of protein import into nucleussearch fatty acid oxidationsearch MyD88-dependent toll-like receptor signaling pathwaysearch toll-like receptor 9 signaling pathwaysearch lipopolysaccharide-mediated signaling pathwaysearch glucose metabolic processsearch regulation of sequence-specific DNA binding transcription factor activitysearch signal transduction in response to DNA damagesearch cellular component movementsearch p38MAPK cascadesearch regulation of transcription from RNA polymerase II promotersearch positive regulation of muscle cell differentiationsearch cellular response to vascular endothelial growth factor stimulussearch cellular response to lipopolysaccharidesearch phosphorylationsearch myoblast differentiation involved in skeletal muscle regenerationsearch neurotrophin TRK receptor signaling pathwaysearch cellular response to ionizing radiationsearch apoptotic processsearch chemotaxissearch toll-like receptor TLR1:TLR2 signaling pathwaysearch toll-like receptor 5 signaling pathwaysearch response to muramyl dipeptidesearch chondrocyte differentiationsearch muscle cell differentiationsearch DNA damage checkpointsearch Ras protein signal transductionsearch 3'-UTR-mediated mRNA stabilizationsearch cytosolsearch cytoplasmsearch nucleoplasmsearch nucleussearch mitochondrionsearch extracellular vesicular exosomesearch spindle polesearch cellsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch