3flz Summary


P38 kinase crystal structure in complex WITH 8-Methyl-6-phenoxy-2-(tetrahydro-pyran-4-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one

A publication describing this structure is not available. The depositing authors are Kuglstatter, A.search; Ghate, M.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.23 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 372 residues which is 100% of the natural sequence. Out of 372 residues 347 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 372 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q16539) positive regulation of muscle cell differentiationsearch myoblast differentiation involved in skeletal muscle regenerationsearch cellular response to lipopolysaccharidesearch activation of MAPK activitysearch negative regulation of canonical Wnt signaling pathwaysearch intracellular signal transductionsearch striated muscle cell differentiationsearch peptidyl-serine phosphorylationsearch toll-like receptor 2 signaling pathwaysearch regulation of transcription, DNA-templatedsearch stress-activated MAPK cascadesearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch neurotrophin TRK receptor signaling pathwaysearch 3'-UTR-mediated mRNA stabilizationsearch signal transduction in response to DNA damagesearch angiogenesissearch p38MAPK cascadesearch response to stresssearch mRNA metabolic processsearch cellular component movementsearch DNA damage checkpointsearch protein phosphorylationsearch vascular endothelial growth factor receptor signaling pathwaysearch stress-induced premature senescencesearch chemotaxissearch toll-like receptor 3 signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch muscle cell differentiationsearch cell morphogenesissearch fatty acid oxidationsearch cartilage condensationsearch MyD88-dependent toll-like receptor signaling pathwaysearch response to muramyl dipeptidesearch blood coagulationsearch gene expressionsearch toll-like receptor 10 signaling pathwaysearch Ras protein signal transductionsearch apoptotic processsearch toll-like receptor 5 signaling pathwaysearch positive regulation of myoblast fusionsearch TRIF-dependent toll-like receptor signaling pathwaysearch regulation of transcription from RNA polymerase II promotersearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of myoblast differentiationsearch phosphorylationsearch positive regulation of blood vessel endothelial cell migrationsearch chondrocyte differentiationsearch cellular response to DNA damage stimulussearch transcription, DNA-templatedsearch toll-like receptor 4 signaling pathwaysearch osteoclast differentiationsearch signal transductionsearch cell surface receptor signaling pathwaysearch RNA metabolic processsearch positive regulation of myotube differentiationsearch regulation of sequence-specific DNA binding transcription factor activitysearch positive regulation of protein import into nucleussearch lipopolysaccharide-mediated signaling pathwaysearch toll-like receptor signaling pathwaysearch toll-like receptor TLR1:TLR2 signaling pathwaysearch innate immune responsesearch toll-like receptor 9 signaling pathwaysearch response to lipopolysaccharidesearch glucose metabolic processsearch cellular response to vascular endothelial growth factor stimulussearch positive regulation of reactive oxygen species metabolic processsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch cellular response to ionizing radiationsearch skeletal muscle tissue developmentsearch positive regulation of erythrocyte differentiationsearch platelet activationsearch NFAT protein bindingsearch protein bindingsearch protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch MAP kinase activitysearch kinase activitysearch MAP kinase kinase activitysearch protein serine/threonine kinase activitysearch nucleotide bindingsearch transferase activitysearch cytosolsearch nucleoplasmsearch mitochondrionsearch nucleussearch cytoplasmsearch spindle polesearch extracellular vesicular exosomesearch cellsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch