3flz Summary


P38 kinase crystal structure in complex WITH 8-Methyl-6-phenoxy-2-(tetrahydro-pyran-4-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one

A publication describing this structure is not available. The depositing authors are Kuglstatter, A.search; Ghate, M.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.23 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 372 residues which is 100% of the natural sequence. Out of 372 residues 347 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 372 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) MAP kinase activitysearch protein kinase activitysearch protein bindingsearch protein serine/threonine kinase activitysearch MAP kinase kinase activitysearch nucleotide bindingsearch kinase activitysearch ATP bindingsearch NFAT protein bindingsearch transferase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch osteoclast differentiationsearch Ras protein signal transductionsearch MyD88-dependent toll-like receptor signaling pathwaysearch blood coagulationsearch gene expressionsearch stress-induced premature senescencesearch toll-like receptor 10 signaling pathwaysearch vascular endothelial growth factor receptor signaling pathwaysearch TRIF-dependent toll-like receptor signaling pathwaysearch response to muramyl dipeptidesearch toll-like receptor 3 signaling pathwaysearch regulation of transcription, DNA-templatedsearch chemotaxissearch MyD88-independent toll-like receptor signaling pathwaysearch muscle cell differentiationsearch peptidyl-serine phosphorylationsearch cartilage condensationsearch toll-like receptor signaling pathwaysearch cell morphogenesissearch angiogenesissearch response to lipopolysaccharidesearch RNA metabolic processsearch toll-like receptor 4 signaling pathwaysearch striated muscle cell differentiationsearch signal transductionsearch cell surface receptor signaling pathwaysearch cellular response to DNA damage stimulussearch transcription, DNA-templatedsearch regulation of sequence-specific DNA binding transcription factor activitysearch glucose metabolic processsearch toll-like receptor 5 signaling pathwaysearch positive regulation of myoblast fusionsearch apoptotic processsearch positive regulation of blood vessel endothelial cell migrationsearch positive regulation of protein import into nucleussearch chondrocyte differentiationsearch regulation of transcription from RNA polymerase II promotersearch p38MAPK cascadesearch platelet activationsearch cellular response to ionizing radiationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch fatty acid oxidationsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch positive regulation of erythrocyte differentiationsearch positive regulation of myotube differentiationsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch toll-like receptor 9 signaling pathwaysearch skeletal muscle tissue developmentsearch cellular response to vascular endothelial growth factor stimulussearch positive regulation of reactive oxygen species metabolic processsearch innate immune responsesearch positive regulation of myoblast differentiationsearch 3'-UTR-mediated mRNA stabilizationsearch signal transduction in response to DNA damagesearch response to stresssearch mRNA metabolic processsearch positive regulation of transcription from RNA polymerase II promotersearch MAPK cascadesearch cellular component movementsearch intracellular signal transductionsearch stress-activated MAPK cascadesearch negative regulation of canonical Wnt signaling pathwaysearch cellular response to lipopolysaccharidesearch activation of MAPK activitysearch lipopolysaccharide-mediated signaling pathwaysearch neurotrophin TRK receptor signaling pathwaysearch toll-like receptor 2 signaling pathwaysearch positive regulation of muscle cell differentiationsearch phosphorylationsearch DNA damage checkpointsearch nucleussearch nucleoplasmsearch mitochondrionsearch cellsearch extracellular vesicular exosomesearch cytosolsearch cytoplasmsearch spindle polesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch