3fly Summary


P38 kinase crystal structure in complex with 6-(2,4-difluoro-phenoxy)-2-isopropylamino-8-methyl-8h-pyrido[2,3-d]pyrimidin-7-one

A publication describing this structure is not available. The depositing authors are Kuglstatter, A.search; Ghate, M.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 372 residues which is 100% of the natural sequence. Out of 372 residues 347 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 372 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (Q16539) ATP bindingsearch MAP kinase activitysearch protein bindingsearch protein serine/threonine kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch nucleotide bindingsearch MAP kinase kinase activitysearch NFAT protein bindingsearch kinase activitysearch transferase activitysearch nucleoplasmsearch cytosolsearch cytoplasmsearch extracellular vesicular exosomesearch nucleussearch spindle polesearch mitochondrionsearch cellsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch toll-like receptor 5 signaling pathwaysearch 3'-UTR-mediated mRNA stabilizationsearch protein phosphorylationsearch positive regulation of transcription from RNA polymerase II promotersearch gene expressionsearch cellular response to vascular endothelial growth factor stimulussearch vascular endothelial growth factor receptor signaling pathwaysearch positive regulation of myotube differentiationsearch signal transduction in response to DNA damagesearch peptidyl-serine phosphorylationsearch positive regulation of myoblast fusionsearch cellular response to DNA damage stimulussearch MyD88-dependent toll-like receptor signaling pathwaysearch cellular response to ionizing radiationsearch toll-like receptor 2 signaling pathwaysearch toll-like receptor TLR1:TLR2 signaling pathwaysearch apoptotic processsearch toll-like receptor 4 signaling pathwaysearch stress-induced premature senescencesearch toll-like receptor signaling pathwaysearch positive regulation of reactive oxygen species metabolic processsearch cell morphogenesissearch chemotaxissearch skeletal muscle tissue developmentsearch glucose metabolic processsearch chondrocyte differentiationsearch regulation of transcription, DNA-templatedsearch p38MAPK cascadesearch positive regulation of blood vessel endothelial cell migrationsearch mRNA metabolic processsearch toll-like receptor 9 signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch innate immune responsesearch fatty acid oxidationsearch angiogenesissearch lipopolysaccharide-mediated signaling pathwaysearch positive regulation of muscle cell differentiationsearch signal transductionsearch regulation of transcription from RNA polymerase II promotersearch transcription, DNA-templatedsearch toll-like receptor 3 signaling pathwaysearch cartilage condensationsearch phosphorylationsearch positive regulation of erythrocyte differentiationsearch cellular component movementsearch cellular response to lipopolysaccharidesearch DNA damage checkpointsearch response to muramyl dipeptidesearch Ras protein signal transductionsearch osteoclast differentiationsearch blood coagulationsearch toll-like receptor 10 signaling pathwaysearch activation of MAPK activitysearch RNA metabolic processsearch positive regulation of protein import into nucleussearch TRIF-dependent toll-like receptor signaling pathwaysearch response to lipopolysaccharidesearch response to stresssearch platelet activationsearch neurotrophin TRK receptor signaling pathwaysearch intracellular signal transductionsearch striated muscle cell differentiationsearch regulation of sequence-specific DNA binding transcription factor activitysearch cell surface receptor signaling pathwaysearch negative regulation of canonical Wnt signaling pathwaysearch stress-activated MAPK cascadesearch myoblast differentiation involved in skeletal muscle regenerationsearch muscle cell differentiationsearch positive regulation of myoblast differentiationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch