3flw Summary


P38 kinase crystal structure in complex with pamapimod

A publication describing this structure is not available. The depositing authors are Kuglstatter, A.search; Ghate, M.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 372 residues which is 100% of the natural sequence. Out of 372 residues 345 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 372 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q16539) toll-like receptor 2 signaling pathwaysearch positive regulation of muscle cell differentiationsearch positive regulation of erythrocyte differentiationsearch RNA metabolic processsearch neurotrophin TRK receptor signaling pathwaysearch positive regulation of protein import into nucleussearch response to stresssearch skeletal muscle tissue developmentsearch signal transduction in response to DNA damagesearch transcription, DNA-templatedsearch DNA damage checkpointsearch mRNA metabolic processsearch toll-like receptor 3 signaling pathwaysearch positive regulation of reactive oxygen species metabolic processsearch fatty acid oxidationsearch response to muramyl dipeptidesearch regulation of transcription, DNA-templatedsearch signal transductionsearch protein phosphorylationsearch muscle cell differentiationsearch chemotaxissearch osteoclast differentiationsearch cellular response to ionizing radiationsearch lipopolysaccharide-mediated signaling pathwaysearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch striated muscle cell differentiationsearch regulation of sequence-specific DNA binding transcription factor activitysearch angiogenesissearch toll-like receptor 4 signaling pathwaysearch myoblast differentiation involved in skeletal muscle regenerationsearch toll-like receptor 5 signaling pathwaysearch cell morphogenesissearch peptidyl-serine phosphorylationsearch positive regulation of myoblast differentiationsearch positive regulation of blood vessel endothelial cell migrationsearch negative regulation of canonical Wnt signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch toll-like receptor TLR1:TLR2 signaling pathwaysearch 3'-UTR-mediated mRNA stabilizationsearch stress-induced premature senescencesearch cellular response to vascular endothelial growth factor stimulussearch p38MAPK cascadesearch vascular endothelial growth factor receptor signaling pathwaysearch apoptotic processsearch stress-activated MAPK cascadesearch intracellular signal transductionsearch platelet activationsearch MyD88-dependent toll-like receptor signaling pathwaysearch regulation of transcription from RNA polymerase II promotersearch cellular response to lipopolysaccharidesearch toll-like receptor 10 signaling pathwaysearch cellular response to DNA damage stimulussearch innate immune responsesearch blood coagulationsearch positive regulation of myotube differentiationsearch gene expressionsearch phosphorylationsearch positive regulation of myoblast fusionsearch activation of MAPK activitysearch cartilage condensationsearch cellular component movementsearch glucose metabolic processsearch Ras protein signal transductionsearch response to lipopolysaccharidesearch TRIF-dependent toll-like receptor signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch toll-like receptor 9 signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch toll-like receptor signaling pathwaysearch chondrocyte differentiationsearch cell surface receptor signaling pathwaysearch MAP kinase activitysearch protein bindingsearch protein serine/threonine kinase activitysearch NFAT protein bindingsearch kinase activitysearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch transferase activitysearch nucleotide bindingsearch MAP kinase kinase activitysearch nucleussearch cytoplasmsearch nucleoplasmsearch cytosolsearch mitochondrionsearch cellsearch extracellular vesicular exosomesearch spindle polesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch