3flq Summary


P38 kinase crystal structure in complex with 6-(2,4-difluoro-phenoxy)-2-((s)-2-methanesulfonyl-1-methyl-ethylamino)-8-methyl-8h-pyrido[2,3-d]pyrimidin

A publication describing this structure is not available. The depositing authors are Kuglstatter, A.search; Knapp, M.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 372 residues which is 100% of the natural sequence. Out of 372 residues 345 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 372 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) ATP bindingsearch protein bindingsearch nucleotide bindingsearch protein kinase activitysearch kinase activitysearch MAP kinase kinase activitysearch MAP kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch NFAT protein bindingsearch transferase activitysearch angiogenesissearch glucose metabolic processsearch DNA damage checkpointsearch toll-like receptor 3 signaling pathwaysearch osteoclast differentiationsearch response to lipopolysaccharidesearch response to stresssearch myoblast differentiation involved in skeletal muscle regenerationsearch cell surface receptor signaling pathwaysearch chondrocyte differentiationsearch mRNA metabolic processsearch toll-like receptor 4 signaling pathwaysearch innate immune responsesearch peptidyl-serine phosphorylationsearch neurotrophin TRK receptor signaling pathwaysearch positive regulation of myotube differentiationsearch protein phosphorylationsearch platelet activationsearch Ras protein signal transductionsearch positive regulation of transcription from RNA polymerase II promotersearch striated muscle cell differentiationsearch positive regulation of muscle cell differentiationsearch positive regulation of myoblast differentiationsearch MyD88-independent toll-like receptor signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch chemotaxissearch toll-like receptor 2 signaling pathwaysearch toll-like receptor 9 signaling pathwaysearch transcription, DNA-templatedsearch positive regulation of myoblast fusionsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch skeletal muscle tissue developmentsearch negative regulation of canonical Wnt signaling pathwaysearch cell morphogenesissearch vascular endothelial growth factor receptor signaling pathwaysearch cellular response to lipopolysaccharidesearch activation of MAPK activitysearch regulation of transcription from RNA polymerase II promotersearch MyD88-dependent toll-like receptor signaling pathwaysearch toll-like receptor TLR1:TLR2 signaling pathwaysearch RNA metabolic processsearch signal transductionsearch regulation of transcription, DNA-templatedsearch cellular response to ionizing radiationsearch p38MAPK cascadesearch response to muramyl dipeptidesearch signal transduction in response to DNA damagesearch TRIF-dependent toll-like receptor signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch positive regulation of reactive oxygen species metabolic processsearch gene expressionsearch stress-activated MAPK cascadesearch intracellular signal transductionsearch toll-like receptor 10 signaling pathwaysearch positive regulation of protein import into nucleussearch lipopolysaccharide-mediated signaling pathwaysearch cartilage condensationsearch toll-like receptor signaling pathwaysearch 3'-UTR-mediated mRNA stabilizationsearch blood coagulationsearch toll-like receptor 5 signaling pathwaysearch stress-induced premature senescencesearch cellular response to vascular endothelial growth factor stimulussearch positive regulation of blood vessel endothelial cell migrationsearch apoptotic processsearch phosphorylationsearch positive regulation of erythrocyte differentiationsearch muscle cell differentiationsearch fatty acid oxidationsearch cellular response to DNA damage stimulussearch cellular component movementsearch nucleoplasmsearch cytosolsearch nucleussearch mitochondrionsearch cytoplasmsearch extracellular vesicular exosomesearch spindle polesearch cellsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch