3fln Summary


P38 kinase crystal structure in complex with R1487

A publication describing this structure is not available. The depositing authors are Kuglstatter, A.search; Knapp, M.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 372 residues which is 100% of the natural sequence. Out of 372 residues 343 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
C Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 372 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
C (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
C (Q16539) protein bindingsearch MAP kinase activitysearch protein serine/threonine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch NFAT protein bindingsearch kinase activitysearch transferase activitysearch nucleotide bindingsearch MAP kinase kinase activitysearch nucleoplasmsearch nucleussearch cytosolsearch cytoplasmsearch spindle polesearch extracellular vesicular exosomesearch cellsearch mitochondrionsearch blood coagulationsearch muscle cell differentiationsearch transcription, DNA-templatedsearch vascular endothelial growth factor receptor signaling pathwaysearch cellular response to ionizing radiationsearch fatty acid oxidationsearch signal transductionsearch toll-like receptor signaling pathwaysearch MyD88-dependent toll-like receptor signaling pathwaysearch response to stresssearch intracellular signal transductionsearch osteoclast differentiationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch DNA damage checkpointsearch regulation of transcription, DNA-templatedsearch cellular response to DNA damage stimulussearch protein phosphorylationsearch positive regulation of myoblast fusionsearch regulation of transcription from RNA polymerase II promotersearch p38MAPK cascadesearch peptidyl-serine phosphorylationsearch positive regulation of blood vessel endothelial cell migrationsearch gene expressionsearch mRNA metabolic processsearch toll-like receptor 4 signaling pathwaysearch toll-like receptor 5 signaling pathwaysearch toll-like receptor 9 signaling pathwaysearch innate immune responsesearch stress-activated MAPK cascadesearch response to lipopolysaccharidesearch positive regulation of myotube differentiationsearch chondrocyte differentiationsearch chemotaxissearch positive regulation of myoblast differentiationsearch cellular component movementsearch Ras protein signal transductionsearch apoptotic processsearch MyD88-independent toll-like receptor signaling pathwaysearch negative regulation of canonical Wnt signaling pathwaysearch toll-like receptor 2 signaling pathwaysearch skeletal muscle tissue developmentsearch positive regulation of transcription from RNA polymerase II promotersearch lipopolysaccharide-mediated signaling pathwaysearch cellular response to lipopolysaccharidesearch cell surface receptor signaling pathwaysearch platelet activationsearch response to muramyl dipeptidesearch phosphorylationsearch 3'-UTR-mediated mRNA stabilizationsearch neurotrophin TRK receptor signaling pathwaysearch positive regulation of erythrocyte differentiationsearch angiogenesissearch cell morphogenesissearch toll-like receptor 3 signaling pathwaysearch cellular response to vascular endothelial growth factor stimulussearch activation of MAPK activitysearch striated muscle cell differentiationsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch positive regulation of muscle cell differentiationsearch myoblast differentiation involved in skeletal muscle regenerationsearch RNA metabolic processsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch toll-like receptor 10 signaling pathwaysearch positive regulation of reactive oxygen species metabolic processsearch cartilage condensationsearch stress-induced premature senescencesearch positive regulation of protein import into nucleussearch regulation of sequence-specific DNA binding transcription factor activitysearch glucose metabolic processsearch signal transduction in response to DNA damagesearch TRIF-dependent toll-like receptor signaling pathwaysearch

Chain InterPro annotation
C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch