3fko Summary


P38 kinase crystal structure in complex with RO3668

A publication describing this structure is not available. The depositing authors are Kuglstatter, A.search; Knapp, M.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 372 residues which is 100% of the natural sequence. Out of 372 residues 343 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 372 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) ATP bindingsearch MAP kinase activitysearch protein kinase activitysearch protein bindingsearch NFAT protein bindingsearch kinase activitysearch nucleotide bindingsearch protein serine/threonine kinase activitysearch transferase activitysearch MAP kinase kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch apoptotic processsearch positive regulation of myoblast differentiationsearch TRIF-dependent toll-like receptor signaling pathwaysearch lipopolysaccharide-mediated signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch toll-like receptor TLR1:TLR2 signaling pathwaysearch cell surface receptor signaling pathwaysearch Ras protein signal transductionsearch cartilage condensationsearch regulation of transcription, DNA-templatedsearch response to stresssearch cellular response to lipopolysaccharidesearch striated muscle cell differentiationsearch positive regulation of reactive oxygen species metabolic processsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch phosphorylationsearch mRNA metabolic processsearch MyD88-dependent toll-like receptor signaling pathwaysearch positive regulation of protein import into nucleussearch peptidyl-serine phosphorylationsearch MAPK cascadesearch cellular response to ionizing radiationsearch glucose metabolic processsearch osteoclast differentiationsearch toll-like receptor 9 signaling pathwaysearch stress-activated MAPK cascadesearch transcription, DNA-templatedsearch intracellular signal transductionsearch skeletal muscle tissue developmentsearch signal transduction in response to DNA damagesearch p38MAPK cascadesearch platelet activationsearch toll-like receptor 3 signaling pathwaysearch response to muramyl dipeptidesearch muscle cell differentiationsearch negative regulation of canonical Wnt signaling pathwaysearch gene expressionsearch RNA metabolic processsearch cellular component movementsearch 3'-UTR-mediated mRNA stabilizationsearch vascular endothelial growth factor receptor signaling pathwaysearch cell morphogenesissearch positive regulation of transcription from RNA polymerase II promotersearch chondrocyte differentiationsearch positive regulation of myotube differentiationsearch fatty acid oxidationsearch cellular response to DNA damage stimulussearch positive regulation of myoblast fusionsearch stress-induced premature senescencesearch angiogenesissearch toll-like receptor 10 signaling pathwaysearch positive regulation of blood vessel endothelial cell migrationsearch toll-like receptor 5 signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch regulation of transcription from RNA polymerase II promotersearch cellular response to vascular endothelial growth factor stimulussearch blood coagulationsearch chemotaxissearch toll-like receptor signaling pathwaysearch response to lipopolysaccharidesearch positive regulation of muscle cell differentiationsearch toll-like receptor 4 signaling pathwaysearch DNA damage checkpointsearch activation of MAPK activitysearch toll-like receptor 2 signaling pathwaysearch innate immune responsesearch signal transductionsearch positive regulation of erythrocyte differentiationsearch regulation of sequence-specific DNA binding transcription factor activitysearch neurotrophin TRK receptor signaling pathwaysearch nucleoplasmsearch cytoplasmsearch extracellular vesicular exosomesearch spindle polesearch nucleussearch cytosolsearch cellsearch mitochondrionsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch