3fko Summary


P38 kinase crystal structure in complex with RO3668

A publication describing this structure is not available. The depositing authors are Kuglstatter, A.search; Knapp, M.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 372 residues which is 100% of the natural sequence. Out of 372 residues 343 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 372 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (Q16539) toll-like receptor signaling pathwaysearch activation of MAPK activitysearch toll-like receptor 4 signaling pathwaysearch striated muscle cell differentiationsearch blood coagulationsearch positive regulation of myoblast fusionsearch positive regulation of muscle cell differentiationsearch response to lipopolysaccharidesearch toll-like receptor 2 signaling pathwaysearch innate immune responsesearch fatty acid oxidationsearch signal transductionsearch chemotaxissearch DNA damage checkpointsearch peptidyl-serine phosphorylationsearch protein phosphorylationsearch transcription, DNA-templatedsearch TRIF-dependent toll-like receptor signaling pathwaysearch positive regulation of myotube differentiationsearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of reactive oxygen species metabolic processsearch response to stresssearch cell surface receptor signaling pathwaysearch positive regulation of myoblast differentiationsearch Ras protein signal transductionsearch MyD88-independent toll-like receptor signaling pathwaysearch toll-like receptor TLR1:TLR2 signaling pathwaysearch regulation of transcription, DNA-templatedsearch cellular response to lipopolysaccharidesearch gene expressionsearch angiogenesissearch response to muramyl dipeptidesearch 3'-UTR-mediated mRNA stabilizationsearch cellular component movementsearch RNA metabolic processsearch vascular endothelial growth factor receptor signaling pathwaysearch phosphorylationsearch osteoclast differentiationsearch positive regulation of erythrocyte differentiationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch positive regulation of protein import into nucleussearch toll-like receptor 9 signaling pathwaysearch stress-activated MAPK cascadesearch cartilage condensationsearch negative regulation of canonical Wnt signaling pathwaysearch intracellular signal transductionsearch p38MAPK cascadesearch signal transduction in response to DNA damagesearch platelet activationsearch toll-like receptor 3 signaling pathwaysearch muscle cell differentiationsearch cell morphogenesissearch lipopolysaccharide-mediated signaling pathwaysearch cellular response to DNA damage stimulussearch apoptotic processsearch MyD88-dependent toll-like receptor signaling pathwaysearch skeletal muscle tissue developmentsearch glucose metabolic processsearch mRNA metabolic processsearch cellular response to ionizing radiationsearch regulation of transcription from RNA polymerase II promotersearch toll-like receptor 5 signaling pathwaysearch positive regulation of blood vessel endothelial cell migrationsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch cellular response to vascular endothelial growth factor stimulussearch myoblast differentiation involved in skeletal muscle regenerationsearch stress-induced premature senescencesearch toll-like receptor 10 signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch chondrocyte differentiationsearch neurotrophin TRK receptor signaling pathwaysearch nucleoplasmsearch cytosolsearch nucleussearch cytoplasmsearch spindle polesearch extracellular vesicular exosomesearch mitochondrionsearch cellsearch protein bindingsearch nucleotide bindingsearch MAP kinase kinase activitysearch NFAT protein bindingsearch MAP kinase activitysearch protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch kinase activitysearch transferase activitysearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch