3fkn Summary

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P38 kinase crystal structure in complex with RO7125

A publication describing this structure is not available. The depositing authors are Kuglstatter, A.search; Ghate, M.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 372 residues which is 100% of the natural sequence. Out of 372 residues 346 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 372 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q16539) protein phosphorylationsearch stress-activated MAPK cascadesearch activation of MAPK activitysearch toll-like receptor 2 signaling pathwaysearch toll-like receptor 5 signaling pathwaysearch response to lipopolysaccharidesearch DNA damage checkpointsearch positive regulation of myoblast differentiationsearch intracellular signal transductionsearch cell morphogenesissearch regulation of transcription from RNA polymerase II promotersearch osteoclast differentiationsearch positive regulation of myotube differentiationsearch response to muramyl dipeptidesearch response to stresssearch toll-like receptor TLR1:TLR2 signaling pathwaysearch Ras protein signal transductionsearch regulation of transcription, DNA-templatedsearch cell surface receptor signaling pathwaysearch toll-like receptor signaling pathwaysearch positive regulation of reactive oxygen species metabolic processsearch RNA metabolic processsearch positive regulation of erythrocyte differentiationsearch positive regulation of blood vessel endothelial cell migrationsearch platelet activationsearch chondrocyte differentiationsearch stress-induced premature senescencesearch positive regulation of protein import into nucleussearch lipopolysaccharide-mediated signaling pathwaysearch p38MAPK cascadesearch TRIF-dependent toll-like receptor signaling pathwaysearch toll-like receptor 3 signaling pathwaysearch myoblast differentiation involved in skeletal muscle regenerationsearch blood coagulationsearch positive regulation of myoblast fusionsearch transcription, DNA-templatedsearch fatty acid oxidationsearch peptidyl-serine phosphorylationsearch negative regulation of canonical Wnt signaling pathwaysearch chemotaxissearch apoptotic processsearch MyD88-independent toll-like receptor signaling pathwaysearch cartilage condensationsearch neurotrophin TRK receptor signaling pathwaysearch MyD88-dependent toll-like receptor signaling pathwaysearch vascular endothelial growth factor receptor signaling pathwaysearch toll-like receptor 9 signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch muscle cell differentiationsearch gene expressionsearch positive regulation of muscle cell differentiationsearch toll-like receptor 10 signaling pathwaysearch 3'-UTR-mediated mRNA stabilizationsearch cellular component movementsearch toll-like receptor 4 signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch cellular response to vascular endothelial growth factor stimulussearch mRNA metabolic processsearch striated muscle cell differentiationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch phosphorylationsearch positive regulation of transcription from RNA polymerase II promotersearch signal transduction in response to DNA damagesearch cellular response to ionizing radiationsearch skeletal muscle tissue developmentsearch glucose metabolic processsearch signal transductionsearch cellular response to lipopolysaccharidesearch innate immune responsesearch angiogenesissearch cellular response to DNA damage stimulussearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch MAP kinase activitysearch kinase activitysearch protein serine/threonine kinase activitysearch protein bindingsearch NFAT protein bindingsearch transferase activitysearch nucleotide bindingsearch MAP kinase kinase activitysearch nucleoplasmsearch cytoplasmsearch nucleussearch cellsearch cytosolsearch spindle polesearch mitochondrionsearch extracellular vesicular exosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch