3fi4 Summary


P38 kinase crystal structure in complex with RO4499

A publication describing this structure is not available. The depositing authors are Kuglstatter, A.search; Knapp, M.search; Dunten, P.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 372 residues which is 100% of the natural sequence. Out of 372 residues 339 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 372 91%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) protein bindingsearch MAP kinase activitysearch ATP bindingsearch NFAT protein bindingsearch protein serine/threonine kinase activitysearch kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch MAP kinase kinase activitysearch nucleotide bindingsearch transferase activitysearch protein phosphorylationsearch MyD88-independent toll-like receptor signaling pathwaysearch positive regulation of protein import into nucleussearch gene expressionsearch stress-induced premature senescencesearch MyD88-dependent toll-like receptor signaling pathwaysearch RNA metabolic processsearch regulation of transcription, DNA-templatedsearch transcription, DNA-templatedsearch positive regulation of myoblast fusionsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch negative regulation of canonical Wnt signaling pathwaysearch positive regulation of myoblast differentiationsearch p38MAPK cascadesearch toll-like receptor signaling pathwaysearch cellular response to lipopolysaccharidesearch neurotrophin TRK receptor signaling pathwaysearch chemotaxissearch osteoclast differentiationsearch lipopolysaccharide-mediated signaling pathwaysearch innate immune responsesearch stress-activated MAPK cascadesearch toll-like receptor 2 signaling pathwaysearch toll-like receptor 9 signaling pathwaysearch cellular response to ionizing radiationsearch positive regulation of reactive oxygen species metabolic processsearch response to stresssearch cartilage condensationsearch positive regulation of myotube differentiationsearch apoptotic processsearch intracellular signal transductionsearch toll-like receptor 4 signaling pathwaysearch toll-like receptor 10 signaling pathwaysearch muscle cell differentiationsearch peptidyl-serine phosphorylationsearch positive regulation of transcription from RNA polymerase II promotersearch skeletal muscle tissue developmentsearch toll-like receptor 5 signaling pathwaysearch angiogenesissearch Ras protein signal transductionsearch mRNA metabolic processsearch vascular endothelial growth factor receptor signaling pathwaysearch cell surface receptor signaling pathwaysearch response to lipopolysaccharidesearch striated muscle cell differentiationsearch cellular response to vascular endothelial growth factor stimulussearch toll-like receptor 3 signaling pathwaysearch fatty acid oxidationsearch regulation of sequence-specific DNA binding transcription factor activitysearch positive regulation of erythrocyte differentiationsearch glucose metabolic processsearch TRIF-dependent toll-like receptor signaling pathwaysearch signal transduction in response to DNA damagesearch activation of MAPK activitysearch myoblast differentiation involved in skeletal muscle regenerationsearch response to muramyl dipeptidesearch blood coagulationsearch cellular component movementsearch platelet activationsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch regulation of transcription from RNA polymerase II promotersearch phosphorylationsearch chondrocyte differentiationsearch positive regulation of blood vessel endothelial cell migrationsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch 3'-UTR-mediated mRNA stabilizationsearch DNA damage checkpointsearch signal transductionsearch cellular response to DNA damage stimulussearch cell morphogenesissearch positive regulation of muscle cell differentiationsearch cytosolsearch nucleussearch spindle polesearch nucleoplasmsearch cytoplasmsearch cellsearch mitochondrionsearch extracellular vesicular exosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch