Crystal structure of JNK3 with amino-pyrazole inhibitor, SR-3451
The structure was published by Kamenecka, T., Habel, J., Duckett, D., et al., Shin, Y., Song, X., and LoGrasso, P., in 2009 in a paper entitled "Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.28 Å and deposited in 2008.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Mitogen-activated protein kinase 10. This molecule has the UniProt identifier P53779 (MK10_HUMAN). The sample contained 353 residues which is < 90% of the natural sequence. Out of 353 residues 326 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: