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Crystal structure of JNK3 with amino-pyrazole inhibitor, SR-3451

Source organism: Homo sapiens
Biochemical function: ATP binding
Biological process: protein phosphorylation
Cellular component: not assigned

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EC 2.7.11.24: Mitogen-activated protein kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (MAPKK-activated)
Alternative Name(s):
  • C-Jun N-terminal kinase
  • Dp38
  • ERK
  • ERK1
  • ERK2
  • Extracellular signal-regulated kinase
  • JNK
  • JNK3-alpha-1
  • LeMPK3
  • MAP kinase
  • MAP-2 kinase
  • MAPK
  • MBP kinase I
  • MBP kinase II
  • Microtubule-associated protein 2 kinase
  • Microtubule-associated protein kinase
  • Myelin basic protein kinase
  • P38-2
  • P38-delta
  • P42 mitogen-activated protein kinase
  • P42(mapk)
  • P44mpk
  • PMK-1
  • PMK-2
  • PMK-3
  • Pp42
  • Pp44(mapk)
  • SAPK
  • STK26
  • Stress-activated protein kinase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00069
Domain description: Protein kinase domain
Occurring in:
  1. Mitogen-activated protein kinase 10
The deposited structure of PDB entry 3fi2 contains 1 copy of Pfam domain PF00069 (Protein kinase domain) in Mitogen-activated protein kinase 10. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR008351
Domain description: Mitogen-activated protein (MAP) kinase, JNK
Occurring in:
  1. Mitogen-activated protein kinase 10
IPR008271
Domain description: Serine/threonine-protein kinase, active site
Occurring in:
  1. Mitogen-activated protein kinase 10
IPR003527
Domain description: Mitogen-activated protein (MAP) kinase, conserved site
Occurring in:
  1. Mitogen-activated protein kinase 10
IPR000719
Domain description: Protein kinase domain
Occurring in:
  1. Mitogen-activated protein kinase 10
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Mitogen-activated protein kinase 10

Structure domains

CATH CATH domains
1.10.510.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Transferase(Phosphotransferase); domain 1
Homology: Transferase(Phosphotransferase) domain 1
Occurring in:
  1. Mitogen-activated protein kinase 10
The deposited structure of PDB entry 3fi2 contains 1 copy of CATH domain 1.10.510.10 (Transferase(Phosphotransferase); domain 1) in Mitogen-activated protein kinase 10. Showing 1 copy in chain A.
3.30.200.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Phosphorylase Kinase; domain 1
Homology: Phosphorylase Kinase; domain 1
Occurring in:
  1. Mitogen-activated protein kinase 10
The deposited structure of PDB entry 3fi2 contains 1 copy of CATH domain 3.30.200.20 (Phosphorylase Kinase; domain 1) in Mitogen-activated protein kinase 10. Showing 1 copy in chain A.

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