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Crystal structure of a complex between the catalytic and regulatory (RI{alpha}) subunits of PKA

X-ray diffraction
2Å resolution
PDB entry 3fhi coloured by chain, front view.
PDB entry 3fhi coloured by chain, side view.
PDB entry 3fhi coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed and cAMP-dependent protein kinase catalytic subunit alpha
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Multimeric state: hetero dimer
Accessible surface area: 20787.18 Å2
Buried surface area: 4276.76 Å2
Dissociation area: 1,575.06 Å2
Dissociation energy (ΔGdiss): 14.31 kcal/mol
Dissociation entropy (TΔSdiss): 12.52 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132579

Macromolecules

cAMP-dependent protein kinase catalytic subunit alpha
Chain: A
Length: 350 amino acids
Theoretical weight: 40.63 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P05132 (Residues: 2-351; Coverage: 100%)
Gene names: Pkaca, Prkaca
Pfam: Protein kinase domain
InterPro:
CATH:
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 3fhi, assembly 1, front view.
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 3fhi, assembly 1, side view.
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 3fhi, assembly 1, top view.
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cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed
Chain: B
Length: 154 amino acids
Theoretical weight: 17.34 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00514 (Residues: 92-245; Coverage: 41%)
Gene name: PRKAR1A
Pfam: Cyclic nucleotide-binding domain
InterPro:
CATH: Jelly Rolls
cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed in PDB entry 3fhi, assembly 1, front view.
cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed in PDB entry 3fhi, assembly 1, side view.
cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed in PDB entry 3fhi, assembly 1, top view.
Molecule details ›

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