3fgu Summary


Catalytic complex of Human Glucokinase

The structure was published by Petit, P., Antoine, M., Ferry, G., et al., Gluais, L., Vincentelli, R., and Vuillard, L., in 2011 in a paper entitled "The active conformation of human glucokinase is not altered by allosteric activators" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.15 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Glucokinase. This molecule has the UniProt identifier P35557 (HXK4_HUMAN)search. The sample contained 470 residues which is 98% of the natural sequence. Out of 470 residues 447 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucokinase P35557 (12-465) (HXK4_HUMAN)search Homo sapienssearch 97% 470 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35557 (12 - 465) Glucokinase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P35557) Hexokinase; domain 1search, Nucleotidyltransferase; domain 5search PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P35557) carbohydrate metabolic processsearch detection of glucosesearch metabolic processsearch positive regulation of insulin secretionsearch positive regulation of cytosolic calcium ion concentrationsearch calcium ion importsearch glycogen biosynthetic processsearch glucose metabolic processsearch second-messenger-mediated signalingsearch carbohydrate phosphorylationsearch glucose homeostasissearch positive regulation of phosphorylationsearch glycolytic processsearch positive regulation of glycolytic processsearch negative regulation of gluconeogenesissearch glucose 6-phosphate metabolic processsearch fructose 2,6-bisphosphate metabolic processsearch regulation of potassium ion transportsearch cellular response to leptin stimulussearch transmembrane transportsearch regulation of glucose transportsearch cellular glucose homeostasissearch endocrine pancreas developmentsearch cellular response to insulin stimulussearch response to glucosesearch negative regulation of epinephrine secretionsearch pathogenesissearch hexose transportsearch phosphorylationsearch cellular response to glucose starvationsearch positive regulation of glycogen biosynthetic processsearch NADP metabolic processsearch regulation of insulin secretionsearch small molecule metabolic processsearch lipid homeostasissearch regulation of glycolytic processsearch glucose transportsearch phosphotransferase activity, alcohol group as acceptorsearch ATP bindingsearch hexokinase activitysearch glucokinase activitysearch protein bindingsearch protein phosphatase bindingsearch glucose bindingsearch fructokinase activitysearch ADP bindingsearch nucleotide bindingsearch magnesium ion bindingsearch catalytic activitysearch kinase activitysearch mannokinase activitysearch transferase activitysearch cytosolsearch cell cortexsearch cytoplasmsearch nucleoplasmsearch nucleussearch basal cortexsearch mitochondrionsearch secretory granulesearch actin filamentsearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch