3fgu Summary


Catalytic complex of Human Glucokinase

The structure was published by Petit, P., Antoine, M., Ferry, G., et al., Gluais, L., Vincentelli, R., and Vuillard, L., in 2011 in a paper entitled "The active conformation of human glucokinase is not altered by allosteric activators" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.15 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Glucokinase. This molecule has the UniProt identifier P35557 (HXK4_HUMAN)search. The sample contained 470 residues which is 98% of the natural sequence. Out of 470 residues 447 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucokinase P35557 (12-465) (HXK4_HUMAN)search Homo sapienssearch 97% 470 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35557 (12 - 465) Glucokinase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P35557) Hexokinase; domain 1search, Nucleotidyltransferase; domain 5search PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P35557) cellular response to leptin stimulussearch cellular response to insulin stimulussearch cellular glucose homeostasissearch NADP metabolic processsearch positive regulation of insulin secretionsearch regulation of insulin secretionsearch positive regulation of glycolytic processsearch response to glucosesearch glucose metabolic processsearch calcium ion importsearch small molecule metabolic processsearch hexose transportsearch transmembrane transportsearch glucose transportsearch regulation of glycolytic processsearch carbohydrate metabolic processsearch glycolytic processsearch metabolic processsearch endocrine pancreas developmentsearch detection of glucosesearch positive regulation of phosphorylationsearch negative regulation of epinephrine secretionsearch negative regulation of gluconeogenesissearch glucose 6-phosphate metabolic processsearch cellular response to glucose starvationsearch glucose homeostasissearch positive regulation of cytosolic calcium ion concentrationsearch regulation of glucose transportsearch second-messenger-mediated signalingsearch phosphorylationsearch carbohydrate phosphorylationsearch fructose 2,6-bisphosphate metabolic processsearch regulation of potassium ion transportsearch glycogen biosynthetic processsearch positive regulation of glycogen biosynthetic processsearch nucleoplasmsearch nucleussearch cytoplasmsearch cytosolsearch mitochondrionsearch cell cortexsearch secretory granulesearch protein phosphatase bindingsearch transferase activitysearch catalytic activitysearch glucose bindingsearch ATP bindingsearch mannokinase activitysearch phosphotransferase activity, alcohol group as acceptorsearch hexokinase activitysearch protein bindingsearch glucokinase activitysearch fructokinase activitysearch magnesium ion bindingsearch ADP bindingsearch kinase activitysearch nucleotide bindingsearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch