3ffp Summary


X ray structure of the complex between carbonic anhydrase II and LC inhibitors

The structure was published by Crocetti, L., Maresca, A., Temperini, C., et al., Scozzafava, A., Muhlschlegel, F.A., and Supuran, C.T., in 2009 in a paper entitled "A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.81 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
X Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
X (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
X (P00918) carbonate dehydratase activitysearch zinc ion bindingsearch protein bindingsearch metal ion bindingsearch lyase activitysearch one-carbon metabolic processsearch response to estrogensearch small molecule metabolic processsearch carbon dioxide transportsearch response to pHsearch positive regulation of bone resorptionsearch response to organic substancesearch positive regulation of osteoclast differentiationsearch regulation of intracellular pHsearch bicarbonate transportsearch kidney developmentsearch secretionsearch response to zinc ionsearch regulation of anion transportsearch morphogenesis of an epitheliumsearch positive regulation of dipeptide transmembrane transportsearch positive regulation of cellular pH reductionsearch odontogenesis of dentin-containing toothsearch angiotensin-activated signaling pathwaysearch response to steroid hormonesearch basolateral plasma membranesearch apical part of cellsearch extracellular spacesearch plasma membranesearch cytoplasmsearch cytosolsearch membranesearch axonsearch extracellular vesicular exosomesearch microvillussearch

Chain InterPro annotation
X Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch