3feg Summary


Crystal structure of human choline kinase beta in complex with phosphorylated hemicholinium-3 and adenosine nucleotide

The structure was published by Hong, B.S., Allali-Hassani, A., Tempel, W., et al., Dimov, S., Vedadi, M., and Park, H.W., in 2010 in a paper entitled "Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.302 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Choline/ethanolamine kinase. This molecule has the UniProt identifier Q9Y259 (CHKB_HUMAN)search. The sample contained 379 residues which is 91% of the natural sequence. Out of 379 residues 330 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Choline/ethanolamine kinase Q9Y259 (35-395) (CHKB_HUMAN)search Homo sapienssearch 91% 379 88%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9Y259 (35 - 395) Choline/ethanolamine kinase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q9Y259) Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2search PF01633: Choline/ethanolamine kinasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q9Y259) transferase activitysearch ethanolamine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch kinase activitysearch choline kinase activitysearch ATP bindingsearch nucleotide bindingsearch phosphatidylethanolamine biosynthetic processsearch glycerophospholipid biosynthetic processsearch lipid metabolic processsearch phosphatidylcholine biosynthetic processsearch phospholipid biosynthetic processsearch CDP-choline pathwaysearch phosphorylationsearch small molecule metabolic processsearch phospholipid metabolic processsearch cytosolsearch cytoplasmsearch

Chain InterPro annotation
A Protein kinase-like domainsearch Choline/Ethanolamine kinasesearch