3fc1 Summary

pdbe.org/3fc1
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Crystal structure of p38 kinase bound to pyrimido-pyridazinone inhibitor

The structure was published by Pearlman, D.A., in 2005 in a paper entitled "Evaluating the molecular mechanics poisson-boltzmann surface area free energy method using a congeneric series of ligands to p38 MAP kinase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier B4E0K5 (B4E0K5_HUMAN)search. The sample contained 366 residues which is 100% of the natural sequence. Out of 366 residues 329 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
X Mitogen-activated protein kinase 14 B4E0K5 (1-283) (B4E0K5_HUMAN)search Homo sapienssearch 100% 366 91%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
B4E0K5 (1 - 283) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
X (Q16539)

Chain ID Biological process (GO) Molecular function (GO)
X (B4E0K5) protein phosphorylationsearch MAPK cascadesearch phosphorylationsearch MAP kinase activitysearch protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch kinase activitysearch

Chain InterPro annotation
X Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch